{"id":13817,"date":"2024-08-02T10:30:23","date_gmt":"2024-08-02T14:30:23","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=13817"},"modified":"2024-08-19T16:15:24","modified_gmt":"2024-08-19T20:15:24","slug":"research-finds-that-cbg-can-impede-glioblastoma-cell-growth","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/","title":{"rendered":"Research Finds That CBG Can Impede Glioblastoma Cell Growth"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cannabis has long been used to aid with the treatment of cancer due to its ability to reduce <a href=\"https:\/\/www.veriheal.com\/conditions\/nausea\/\">nausea<\/a>, reduce inflammation, stimulate appetite and reduce pain while promoting homeostasis in the body. Many forms of cancer are aggressive, but glioblastoma is said to be especially so. <\/span><span style=\"font-weight: 400;\">Glioblastoma is not often caught early as the initial symptoms are non-specific and include headaches, nausea, and personality deviation. Much of glioblastoma is still unknown but the typical survival duration after diagnosis is between 12 to 15 months. <\/span><span style=\"font-weight: 400;\">Fortunately, a group of trailblazers has found a way to impede (delay or prevent) cell growth in Glioblastoma patients. The team found that a cannabinoid known as CBG is the key to impeding the growth of glioblastoma cells, in turn extending life expectancy and reducing the effects of the condition.\u00a0<\/span><\/p>\n<h2><b>What is CBG?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.veriheal.com\/blog\/what-you-should-know-about-cbg-and-its-health-benefits\/\">CBG, or Cannabigerol<\/a>, is a cannabinoid compound from the cannabis plant. The cannabinoid can be located amongst other cannabinoids such as Tetrahydrocannabinol (THC) and Cannabidiol (CBD), which are more commonly known. What many people do not know is that THC and CBD have somewhat of a mother cannabinoid, which is CBG. This mother-like cannabinoid produces an acid, CBGA (cannabigerolic acid), which acts as a precursor to THCA (tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), and CBCA (cannabichromenic acid). The CBGA is broken down by enzymes and is sent throughout the plant to the other acids. Once these are exposed to heat or ultraviolet light, they come to the cannabis we know and love <a href=\"https:\/\/www.veriheal.com\/blog\/uncovering-thc-the-cannabis-plants-most-famous-cannabinoid\/\">THC<\/a>, <a href=\"https:\/\/www.veriheal.com\/blog\/veriheals-complete-guide-to-cbd-heres-everything-you-need-to-know\/\">CBD<\/a>, and CBC (Cannabichromene).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CBG has been found to act <\/span><span style=\"font-weight: 400;\">as a vasodilator and appears to have neuroprotective effects, anti-inflammatory properties as well as many of the health benefits found in other cannabinoids such as THC and CBD. Which makes sense when considering that this compound is \u201cthe mother\u201d to cannabinoids. However, this cannabinoid is far less understood in comparison to infamous cannabinoids CBD and THC.\u00a0<\/span><\/p>\n<h2><b>What is Glioblastoma?\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Glioblastoma is one of the most aggressive forms of cancer and usually occurs in the brain and spinal cord. Glioblastoma is also known as glioblastoma multiforme and is caused by cells called astrocytes. Most of the time, a cure is not possible and treatment is only used to slow progression as well as to reduce signs and symptoms.\u00a0<\/span><a href=\"https:\/\/www.britannica.com\/science\/astrocyte\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Astrocytes are star-shaped cells<\/span><\/a><span style=\"font-weight: 400;\">, which are a type of neuroglia found in the nervous system of invertebrates and vertebrates. Astrocytes are categorized into fibrous astrocytes and protoplasmic astrocytes. The astrocytes are supportive of the nervous system and <\/span><span style=\"font-weight: 400;\">are responsible for communication between the brain and spinal to the rest of the body parts.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Glioblastoma can therefore be a brain or spinal cancer and is said to have a complex biology, despite decades of dedicated research on the matter. <\/span><span style=\"font-weight: 400;\">This form of cancer is \u201c<a href=\"https:\/\/www.researchgate.net\/publication\/319964422_Molecular_Mechanisms_of_Glioma_Cell_Motility\" target=\"_blank\" rel=\"noopener noreferrer\">characterized<\/a> by a rapid and highly infiltrative\u201d growth rate<\/span><span style=\"font-weight: 400;\">. Fortunately, professionals have successfully formulated a novel cannabinoid to act as a treatment for glioblastoma, driven by the goal of finding a cure which then changed to the aims of subduing tumor malignancy, turning cancer into a chronic disease with longer life expectancy\u201d and a better outlook on the quality of life.\u00a0<\/span><\/p>\n<h2><b>How CBG Intercepts Glioblastoma Cell Growth<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">MGC Pharmaceuticals, the Slovenian National Institute of Biology (NIB), and the Neurosurgery Department at the University Medical Centre in Ljubljana (Slovenia)<\/span><span style=\"font-weight: 400;\"> teamed up in efforts to <a href=\"https:\/\/www.europeanpharmaceuticalreview.com\/article\/126323\/a-novel-cannabinoid-formulation-for-glioblastoma-treatment\/\" target=\"_blank\" rel=\"noopener noreferrer\">research and collaborate on a treatment for glioblastoma<\/a>. Earlier in 2020, the collaboration confirmed that they had successful research results on their cannabinoid formation, which was developed with the treatment of glioblastoma in mind.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since glioblastoma is one of the most malignant cancer types and considering the low survival rates, finding an effective treatment has never been more necessary. The team of researchers explained that within the cannabis plant, there are several phytochemicals (chemical compounds from plants) that possess important properties for fighting against glioblastoma, including the compounds THC and CBD. <\/span><span style=\"font-weight: 400;\">The team explains that these cannabis phytochemicals are able to \u201cbind to specific transmembrane proteins\u201d, which then \u201cfacilitate entrance into the glioblastoma cells\u201d. By entering the glioblastoma cells, cannabis is interfering with its biochemical pathway, promotes the cancerous cells\u2019 growth arrest- which means that the growth of the glioblastoma cells will not function properly, inhibit their invasion, or in other words, stopping its spread and causing cell death in glioblastoma.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The aim of the team was to develop an effective cannabinoid combination and define the protocols for treating glioblastoma patients. While the study assessed mainly THC, CBD, and CBC, the results of their efforts revealed that CBG is the key. Cannabigerol, or CBG, is a non-intoxicating compound. When the team combined the CBD with the key, CBG, they found that the cytotoxicity (toxicity to glioblastoma cells) doubled. <\/span><span style=\"font-weight: 400;\">The team explains that this doubled toxicity to the glioblastoma cells can be explained by CBD\u2019s ability to inhibit cancer cell viability, while CBG cascades the biological process which leads to \u201cprogrammed death (apoptosis) of GSCs (glioblastoma stem cells)\u201d.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This study&#8217;s results were concluded by stating that \u201c<\/span><span style=\"font-weight: 400;\">The effective power of CBG and CBD to terminate cancer stem cells is completely novel. The ability of this formulation to affect GSCs <\/span><i><span style=\"font-weight: 400;\">in vivo<\/span><\/i><span style=\"font-weight: 400;\">, without the need for THC, would enable the development of a therapeutic intervention which is devoid of its psychotropic effects\u201d. <\/span><span style=\"font-weight: 400;\">The next steps for this team will be to focus on testing the delivery systems with the aim to cross the blood-brain barrier (the BBB).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The fact that CBG is the key to be added to CBD for making cannabis a cancer cell killing compound is quite revolutionary as cannabis is a botanical substance, with far less severe side effects when compared to its man-made counterpart treatments including brutal chemotherapy. It is our hope that research like this continues to surface so that future generations can live in a world where cancer fears cannabis and where people don&#8217;t fear cancer.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cannabis has long been used to aid with the treatment of cancer due to its ability to reduce nausea, reduce inflammation, stimulate appetite and reduce pain while promoting homeostasis in the body. Many forms of cancer are aggressive, but glioblastoma is said to be especially so. Glioblastoma is not often caught early as the initial&#8230;<\/p>\n","protected":false},"author":49,"featured_media":36075,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[255],"tags":[1772,2537,1876,8911],"class_list":["post-13817","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-brain","tag-cancer","tag-cannabis-research","tag-glioblastoma"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Finds That CBG Can Impede Glioblastoma Cell Growth<\/title>\n<meta name=\"description\" content=\"Research suggests that CBG may impede glioblastoma cell growth. 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Learn about this promising development and consult with medical marijuana doctors to explore how CBG could be integrated into your treatment plan for potential benefits.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/\" \/>\n<meta property=\"og:site_name\" content=\"Cannabis Central\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/veriheal\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-02T14:30:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-19T20:15:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2024\/08\/Veriheal-Blog-Template-4A-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Chane Leigh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@veriheal\" \/>\n<meta name=\"twitter:site\" content=\"@veriheal\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Chane Leigh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/\"},\"author\":{\"name\":\"Chane Leigh\",\"@id\":\"https:\/\/www.veriheal.com\/blog\/#\/schema\/person\/73d61739b251752028b4e59ddd92f03b\"},\"headline\":\"Research Finds That CBG Can Impede Glioblastoma Cell Growth\",\"datePublished\":\"2024-08-02T14:30:23+00:00\",\"dateModified\":\"2024-08-19T20:15:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/\"},\"wordCount\":981,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2024\/08\/Veriheal-Blog-Template-4A-1.jpg\",\"keywords\":[\"brain\",\"cancer\",\"cannabis research\",\"glioblastoma\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/#respond\"]}],\"copyrightYear\":\"2024\",\"copyrightHolder\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/\",\"url\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/\",\"name\":\"Research Finds That CBG Can Impede Glioblastoma Cell Growth\",\"isPartOf\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.veriheal.com\/blog\/research-finds-that-cbg-can-impede-glioblastoma-cell-growth\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2024\/08\/Veriheal-Blog-Template-4A-1.jpg\",\"datePublished\":\"2024-08-02T14:30:23+00:00\",\"dateModified\":\"2024-08-19T20:15:24+00:00\",\"description\":\"Research suggests that CBG may impede glioblastoma cell growth. 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