{"id":16003,"date":"2022-01-05T08:00:30","date_gmt":"2022-01-05T13:00:30","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=16003"},"modified":"2025-04-28T14:51:27","modified_gmt":"2025-04-28T18:51:27","slug":"exploring-the-therapeutic-potential-of-ketamine","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/exploring-the-therapeutic-potential-of-ketamine\/","title":{"rendered":"Exploring the Therapeutic Potential of Ketamine"},"content":{"rendered":"

Ketamine, with its “triple-threat of sedative, stimulating, and psychedelic effects,” according to<\/span> The Cut<\/span><\/a>, has a wild and elusive history. First approved by the U.S. Food and Drug Administration (FDA) in 1970<\/span> as a wartime anesthetic<\/a><\/span>, ketamine turned into a popular party drug feared by parents everywhere before eventually being considered as a treatment for depression in the 2000s.<\/span><\/p>\n

The Cut’s account of a ketamine experience, titled <\/span>“Leave Your Body at the Door,”<\/span><\/a>\u00a0explains that the substance \u201cnumbs your body and makes you feel apart from your environment,\u201d and \u201cthat doesn\u2019t begin to capture the weirdness of what it feels like to get high on K [ketamine].\u201d While the drug has become commonly associated with its unique dissociative effects, it turns out to be abundant with quick-acting therapeutic properties too.<\/span><\/p>\n

What Is Ketamine?<\/b><\/h2>\n

Ketamine is categorized as a dissociative anesthetic that sends users into the <\/span>“K-Hole,”<\/span><\/a>\u00a0or \u201cthe full dissociative experience that ravages your speech capabilities and motor functions (8<\/a>).\u201d The ketamine high reportedly feels like \u201cwalking from your kitchen to your living room, and from your living room to your kitchen, and it\u2019s uphill both ways, but you\u2019ve never had so much fun walking up a hill.\u201d<\/span><\/p>\n

Under the Controlled Substance Act (CSA), ketamine is listed as a <\/span>Schedule III drug<\/span><\/a>, meaning the U.S. government considers it to have medical use and \u201ca moderate to low potential for physical and psychological dependence.\u201d It\u2019s approved for use in hospitals and veterinarian clinics but remains illegal for other uses (2<\/a>). Recreational (illegal) ketamine is commonly referred to as K, Special K, Kit Kat, Super K, super acid, and more.<\/span><\/p>\n

Dissociative anesthetics belong to a class of <\/span>psychedelic drugs<\/span><\/a> that distort perception, including sensory perception. <\/span>Medical News Today<\/span><\/a> explains that other drugs belonging to this categorization include phencyclidine (PCP), dextromethorphan (DXM), and nitrous oxide (laughing gas) (1<\/a>). Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, which is why it is useful as anesthesia.<\/span><\/p>\n

Ketamine is <\/span>thought<\/span><\/a> to work like a flash mob, temporarily taking over a certain chemical receptor, which can be a good thing when taken under medical supervision (6<\/a>). So, what does that look like? Let\u2019s find out.<\/span><\/p>\n

Ketamine\u2019s Medical Uses<\/b><\/h2>\n

Ketamine is mostly used in veterinary medicine but can be used on humans as well to induce and maintain general anesthesia before, during, and after surgery. According to Medical News Today, the substance is considered to be a safe anesthetic when taken as prescribed by a doctor (1<\/a>). In fact, it\u2019s a suitable option for less wealthy countries and disaster zones due to the fact that it doesn\u2019t require an electricity supply, oxygen, or highly trained staff.<\/span><\/p>\n

In human medicine, ketamine is utilized as an anesthetic in procedures such as cardiac catheterization, skin grafts, orthopedic procedures, diagnostic procedures on the eye, ears, nose, and throat, and minor surgical interventions such as dental extractions. It can also alleviate pain in small doses and has been used to control seizures, but this is only considered after five or six other treatment options have proven ineffective.<\/span><\/p>\n

Additionally, ketamine has been proven through studies to reduce symptoms associated with <\/span>PTSD<\/span><\/a> and <\/span>depression<\/span><\/a>. One <\/span>2019 study<\/span><\/a> published in the <\/span>Indian Journal of Psychiatry<\/span><\/i> found significant improvement in participants with severe depression after using ketamine for just two weeks and was sustained for a month (7<\/a>). A <\/span>randomized, double-blind, crossover<\/span><\/a> trial <\/span>conducted from 2009 to 2012 discovered ketamine\u2019s ability to significantly and rapidly reduce PTSD symptoms more effectively than midazolam, a medical anxiolytic and sedative.<\/span><\/p>\n

How Is Ketamine Consumed?<\/b><\/h2>\n

Illegal ketamine comes in the form of a white crystalline powder, which can then be made into tablets, pills, or even dissolved into a liquid form. When used as a medical anesthetic, the substance is typically injected into a muscle, snorted nasally, or given through an intravenous (IV) line. When using ketamine as a treatment for depression and other <\/span>psychiatric conditions<\/span><\/a>, health professionals often opt for intranasal esketamine (a selected ketamine enantiomer) or ketamine infusion therapy, which takes a couple of different forms. Only intranasal esketamine (Spravato, S-ketamine) is FDA-approved for refractory depression while other forms like IV are not (3<\/a>).<\/span><\/p>\n

According to <\/span>Pacific Psych Centers<\/span><\/a>, ketamine infusion therapy is used to treat depression symptoms in patients who don\u2019t respond to traditional drugs like selective serotonin reuptake inhibitors (SSRIs) and is believed to repair damage to the brain done by long-term stress. While IV ketamine is considered \u201coff-label\u201d when used as a treatment for depression because it is not approved by the FDA for psychiatric purposes as esketamine is, patients and researchers anecdotally report it to be relatively safe and effective for mental health treatment (5<\/a>).<\/span><\/p>\n

Ketamine infusion therapy is either administered directly into the bloodstream through an IV or as a nasal spray known as esketamine (Spravato). At Pacific Psych Centers, patients \u201ctypically receive a series of six infusions over two to three weeks\u201d before later returning for one infusion every two to six weeks (5<\/a>). While eksetamine is FDA-approved, it is said to be less researched for treating depression and is in need of more research to prove its effectiveness and efficacy.<\/span><\/p>\n

Risks of Using Ketamine<\/b><\/h2>\n

Ketamine is a drug that should be administered by a professional in a medical setting to unlock its true benefits safely. Otherwise, the potential adverse effects of ketamine include (1<\/a>):<\/span><\/p>\n