{"id":20641,"date":"2022-03-02T08:00:45","date_gmt":"2022-03-02T13:00:45","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=20641"},"modified":"2022-02-28T14:11:25","modified_gmt":"2022-02-28T19:11:25","slug":"research-links-runners-high-to-cannabinoid-receptors-in-the-brain","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/research-links-runners-high-to-cannabinoid-receptors-in-the-brain\/","title":{"rendered":"Research Links ‘Runner’s High’ to Cannabinoid Receptors in the Brain"},"content":{"rendered":"

Have you ever wondered why so many people are dedicated to running? While running has a whole list of benefits, one of the main appeals of this form of exercise is what we know as the “runner’s high,” described by Healthline<\/a> as \u201c<\/span>a brief, deeply relaxing state of euphoria<\/span>.\u201d Endorphins<\/a> have long been connected to the runner’s high phenomenon, but <\/span>new research has found<\/span><\/a> that cannabinoid receptors\u2014the very ones cannabinoids from cannabis bind to\u2014play a key role.\u00a0<\/span><\/p>\n

Should Endorphins Be Getting All the Credit?<\/b><\/h2>\n

The research\u2014which summarizes nearly two decades worth of work on the matter\u2014was conducted by Hilary Marusak and a team of other researchers. <\/span>Marusak is a neuroscientist at the Wayne State University School of Medicine, where she uses her lab to study brain development, mental health, and the role of the endocannabinoid system<\/a> in stress regulation and anxiety disorders.<\/span><\/p>\n

According to Marusak, there are several decades worth of research proving that exercise is beneficial for one’s health. Those studies have found a consistent link between physical activity and reduced risks of various conditions, including cancer and heart disease. Scientists initially<\/span> found exercise to increase endorphin levels in blood, delivering a host of effects like pain relief. <\/span><\/p>\n

However, endorphins cannot cross into the brain through the blood-brain barrier, which made researchers wonder if these chemicals could be held fully responsible for the runner’s high sensation. Deeper dives into the matter determined that endorphins \u201care not likely to be the main driver for the beneficial effects of exercise on mood and mental state,\u201d which is where Marusak and her team\u2019s research comes in.<\/span><\/p>\n

To get a better understanding of the runner’s high, the team conducted a systematic review and meta-analysis of 33 published studies that looked into endocannabinoid levels and exercise. They then compared \u201cthe effects of an ‘acute’ exercise session\u2014like going for a 30-minute run or cycle\u2014with the effects of ‘chronic’ programs, such as a 10-week running or weightlifting program.\u201d This division was made because different levels of exertion may have \u201cdistinct effects on endocannabinoid responses.\u201d<\/span><\/p>\n

Endocannabinoids Steal the Spotlight<\/h2>\n

The team found that \u201cexercise readily increases the levels of the body\u2019s endocannabinoids, which are molecules that work to maintain balance in the brain and body\u2014a process called \u2018homeostasis.\u2019\u201d T<\/span>he acute exercises specifically were consistently boosting endocannabinoid levels across the studies they reviewed.<\/span><\/p>\n

In terms of the endocannabinoid levels, they found that those levels were elevated across various types of exercise, including the likes of running, swimming, and even weight-lifting. These results were consistent regardless of any potential preexisting health conditions. Additionally, endocannabinoid levels were raised more effectively from moderate levels of intensity in contrast to lower intensity exercises.<\/span><\/p>\n

Specifically, the effects in those studies were most consistent with a \u201cchemical messenger known as anandamide<\/a>\u2014the so-called \u2018bliss\u2019 molecule, which was named, in part, for its positive effects on mood [as opposed to endorphins].\u201d W<\/span>hile endorphins were thought to be the reason behind the runner\u2019s high, studies now point to endocannabinoids \u201cas the star players in the runner\u2019s high.\u201d <\/span><\/p>\n

According to the researchers, these studies demonstrated that when opioid receptors were blocked, people still experienced euphoria. In comparison, when the cannabinoid receptors were blocked, there was a reduction in the beneficial effects of exercise (the euphoria). So, what exactly are endocannabinoids?\u00a0<\/span><\/p>\n

Endocannabinoids and Runner’s High<\/b><\/h2>\n

Many people do not realize that our bodies make their own versions of cannabinoids like CBD and THC called <\/span>endocannabinoids<\/span>. The “endo” part of endocannabinoid refers \u201cto those [cannabinoid compounds] produced in the body rather than from a plant or in a lab.\u201d\u00a0<\/span><\/p>\n

Just like endocannabinoids, cannabinoids from the cannabis plant bind to the receptors in the endocannabinoid system, which promotes homeostasis in the body. When cannabinoids from the plant bind to the ECS, the number of endocannabinoids is essentially increased\u2014regardless of the fact that the increase does not come from within the body itself. This then means there are more agents in your body that seek to restore balance and health.\u00a0<\/span><\/p>\n

So endocannabinoids and cannabinoids work similarly within the body but are derived from different sources\u2014which is why running does not have the same effect on the body as smoking cannabis. Next time you need a little boost of happiness, try going for a run and feeling your body’s endocannabinoids at work.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Have you ever wondered why so many people are dedicated to running? While running has a whole list of benefits, one of the main appeals of this form of exercise is what we know as the “runner’s high,” described by Healthline as \u201ca brief, deeply relaxing state of euphoria.\u201d Endorphins have long been connected to…<\/p>\n","protected":false},"author":49,"featured_media":21016,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[255,259],"tags":[7906,2052,84,2416,7510,12922,13172],"class_list":["post-20641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research","tag-anandamide","tag-cannabinoids","tag-endocannabinoid-system","tag-endocannabinoids","tag-exercise","tag-runners-high","tag-running"],"acf":[],"yoast_head":"\nCannabis Central<\/title>\n<meta name=\"description\" content=\"New research has uncovered the role of endocannabinoids\u2014as opposed to 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