{"id":25391,"date":"2024-10-08T08:00:01","date_gmt":"2024-10-08T12:00:01","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=25391"},"modified":"2026-04-06T07:37:26","modified_gmt":"2026-04-06T11:37:26","slug":"can-you-safely-use-cannabis-while-being-on-wellbutrin","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/can-you-safely-use-cannabis-while-being-on-wellbutrin\/","title":{"rendered":"Can You Safely Use Cannabis While Being on Wellbutrin?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Have you ever considered using cannabis to treat your depression? If so, you\u2019re not alone. In fact, a growing number of people are turning to this herbal remedy to help improve their mood.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But if you\u2019re taking the antidepressant\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470212\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Wellbutrin (bupropion)<\/span><\/a><span style=\"font-weight: 400;\">, is it\u00a0<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/should-you-consume-cannabis-while-taking-antidepressants\/\"><span style=\"font-weight: 400;\">safe to use cannabis at the same time<\/span><\/a><span style=\"font-weight: 400;\">? Here are some facts you should know before deciding what is right for you.<\/span><\/p>\n<h2><b>What Is Wellbutrin?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Wellbutrin, a brand of bupropion, is a prescription medication that is used to treat\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559078\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">major depressive disorder<\/span><\/a><span style=\"font-weight: 400;\">\u00a0and\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK568745\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seasonal affective disorder<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin is also <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2528204\/#:~:text=A%20recent%20Cochrane%20systematic%20review,%3B%20Hughes%20et%20al%202004).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">used as a smoking cessation aid<\/span><\/a><span style=\"font-weight: 400;\">, as it can help to reduce nicotine cravings and withdrawal symptoms. Regular or extended-release tablets are available, depending on the individual\u2019s response.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some common side effects of Wellbutrin include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excitement<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Over time, these side effects usually diminish as the body adjusts to the medication. Generally, Wellbutrin causes few side effects and works well for treating depression.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bupropion works by increasing the levels of\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537259\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">norepinephrine\u00a0<\/span><\/a><span style=\"font-weight: 400;\">and\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535451\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">dopamine<\/span><\/a><span style=\"font-weight: 400;\">, two types of neurotransmitters, in the brain. In other words, it helps keep those feel-good neurotransmitters circulating for longer, allowing us to make better use of them. As a result, patients who take Wellbutrin may experience a boost in mood and energy levels.<\/span><\/p>\n<h2><b>Wellbutrin Interactions With Marijuana<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">There is little data on weed for depression and even less on mixing weed and Wellbutrin. According to <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33332004\/#:~:text=There%20is%20preclinical%20evidence%20that%20alteration%20in%20the%20endocannabinoid%20system%20could%20potentially%20benefit%20patients%20suffering%20from%20depression.%20However%2C%20the%20issue%20of%20using%20cannabis%20as%20an%20anti%2Ddepressant%20is%20at%20an%20early%20stage%20of%20examination%20and%20there%20is%20little%20evidence%20to%20support%20it.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">a 2021 book published<\/span><\/a><span style=\"font-weight: 400;\"> by <\/span><i><span style=\"font-weight: 400;\">Advances in Experimental Medicine and Biology<\/span><\/i><span style=\"font-weight: 400;\">, scientists find cannabis could be a potential <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33332004\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">remedy for depression<\/span><\/a><span style=\"font-weight: 400;\">, but there is still little evidence to support it.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin may reduce the psychoactive high from cannabis, according to a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3620032\/#:~:text=Results,of%20marijuana%20withdrawal.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2012 study with monkeys<\/span><\/a><span style=\"font-weight: 400;\">. It may also reduce the unpleasant side effects of cannabis withdrawal.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The primate studies initially gave the scientific basis to move forward with human trials on cannabis and Wellbutrin later on. However, clinical studies using Wellbutrin in the context of cannabis use disorder, unfortunately, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9110555\/#:~:text=In%20the%20studies,mood%20%5B64%5D).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">do not show superior effects<\/span><\/a><span style=\"font-weight: 400;\"> to a placebo so far for treating withdrawal symptoms. The combination was at least shown to be safe.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Still, there is evidence that some cannabinoids found in cannabis, such as\u00a0<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cbd\/\"><span style=\"font-weight: 400;\">cannabidiol (CBD)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4204#:~:text=3.5.%20Psychiatric%20Conditions,conflicting%20%5B62%5D.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">boost neurotransmitter activity<\/span><\/a><span style=\"font-weight: 400;\"> and reduce inflammation \u2013 as well as reduce the high from THC. Thus, combining CBD-rich cannabis with Wellbutrin may help improve its overall efficacy, but this is still only based on theory.<\/span><\/p>\n<h2><b>Potential Benefits and Risks of Mixing Cannabis and Wellbutrin<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">In light of the increase in acceptance and popularity of cannabis, it\u2019s essential to consider any potential interactions with other medications when using the plant.\u00a0<\/span><\/p>\n<h3><strong>Potential Benefits<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Some people report that Wellbutrin has\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3411526\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">helped ease their withdrawal symptoms<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0Researchers have explored whether Wellbutrin could help ease\u00a0<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cannabis-withdrawal-syndrome-treatment-options-stimulated-by-yale-study\/\"><span style=\"font-weight: 400;\">cannabis withdrawal symptoms<\/span><\/a><span style=\"font-weight: 400;\"> for people attempting to stop using the plant, but so far only found<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8655458\/#:~:text=Of%20these%20evaluated%20drugs%2C%20Cochrane225%20and%20other%20reviews178%2C216%20have%20found%20limited%20support%20for%20selective%20serotonin%20reuptake%20inhibitors%2C%20the%20antidepressant%20bupropion%2C%20the%20anxiolytic%20buspirone%20and%20the%20selective%20noradrenaline%20reuptake%20inhibitor%20atomoxetine.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">limited support for it<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While marijuana is not commonly thought of as causing physical withdrawal effects, many people develop a\u00a0<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/how-to-manage-withdrawal-from-cannabis-use-disorder\/\"><span style=\"font-weight: 400;\">psychological dependence<\/span><\/a><span style=\"font-weight: 400;\">\u00a0on it and can experience withdrawal symptoms when they try to quit.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pharmacological interventions like Wellbutrin are commonly prescribed for smoking cessation, so the idea remains largely the same here.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On a practical note, some patients find Wellbutrin to be activating or stimulating, which has some implications. <\/span><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.liebertpub.com\/doi\/10.1089\/can.2023.0012#:~:text=The%20WADA%20prohibits,pipradrol%2C%20and%20synephrine.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">a 2023 publication<\/span><\/a><span style=\"font-weight: 400;\"> in <\/span><i><span style=\"font-weight: 400;\">Cannabis and Cannabinoid Research,<\/span><\/i><span style=\"font-weight: 400;\"> Wellbutrin is technically a performance-enhancing (ergogenic) substance. Yet, it isn\u2019t tested for in drug screenings and is still permitted by the World Anti-Doping Agency (WADA).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, cannabis is not only a performance enhancer (non-ergogenic) but also a recognized therapeutic substance. Unfortunately, it remains a common target of drug screenings and a <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cannabis-testing-keeps-qualified-talent-out-of-the-game\/\"><span style=\"font-weight: 400;\">disqualifying factor in many professions<\/span><\/a><span style=\"font-weight: 400;\"> despite its widespread acceptance.<\/span><\/p>\n<h3><strong>Potential Risks<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">The stimulation from Wellbutrin also means that patients generally prefer taking it in the morning because it may otherwise keep them awake at night and cause insomnia or poor-quality sleep.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For some frequent cannabis users, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11401006\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">older evidence from 2001 suggests<\/span><\/a><span style=\"font-weight: 400;\"> that the antidepressant may actually worsen moods during marijuana withdrawal.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Moreover, although many people report positive outcomes when cannabis is combined with Wellbutrin, research suggests the\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470212\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">combination may worsen depression<\/span><\/a><span style=\"font-weight: 400;\">\u00a0for some people, while anxiety or insomnia may increase for others. If you experience worsening depression, that&#8217;s a sign you should talk to your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin is often chosen because it lacks a lot of the side effects that are typical for SSRIs, such as sexual side effects, weight gain, apathy, sleepiness, and withdrawal. This makes it easier to stick to in the long run.<\/span><\/p>\n<h2><b>Final Thoughts<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re thinking about combining Wellbutrin and cannabis, the best thing to do is talk to your doctor or pharmacist first. They will be able to educate you on possible risks and drug interactions that could occur.\u00a0 Note that none of the clinical studies have shown serious side effects, but your personal situation could be different.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While many people can safely combine these two substances, it\u2019s important to understand that every person is different and that what may work for one person might not work for another, so be ready to adjust your routine as necessary for the best possible outcome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are a few tips for if you opt to use cannabis and Wellbutrin together:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Start with a <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/microdosing-cannabis-explained-how-to-do-it-and-why-you-should-try-it\/\"><span style=\"font-weight: 400;\">low dose of cannabis<\/span><\/a><span style=\"font-weight: 400;\">. You can always increase the amount if you need to, but it\u2019s best to start slowly to avoid any potential unwanted effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Be patient. The effects of Wellbutrin may take a few days to weeks or even months to kick in, so don\u2019t give up if you don\u2019t notice an immediate difference.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pay attention to your body. If you feel unusually anxious or agitated, consult your doctor.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">With a little trial and error, you should be able to find the right combination that works for you.<\/span><\/p>\n<h2><b>Frequently Asked Questions<\/b><\/h2>\n<h3><strong>Can I smoke while on Wellbutrin?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">While it is not considered highly dangerous to consume cannabis while taking bupropion, the interactions between this medication and cannabis products are not well-known, especially given that dosing and effectiveness can vary across individuals. Therefore, it is advisable to exercise caution and consult a healthcare provider for advice regarding your specific situation. If you do decide to use cannabis while taking bupropion, start with smaller doses of cannabis and slowly increase it so you can get an idea of how it affects you. So far, there aren&#8217;t any reported serious side effects shown.<\/span><\/p>\n<h3><strong>Does bupropion interact with weed?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Some evidence has shown that cannabis may complement the effectiveness of bupropion\u2019s antidepressant and mood-boosting effects. However, there are also reports that cannabis consumption while on bupropion can increase depression and anxiety, especially for heavy cannabis users.\u00a0<\/span><\/p>\n<h3><strong>What drugs cannot be taken with Wellbutrin?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Certain drugs can increase the chance that you will experience side effects from Wellbutrin, with seizures posing the most serious risk to users of the medication. Always follow a healthcare professional\u2019s instructions when taking prescription medication, and ask your provider about the safety of taking Wellbutrin with other substances, such as cannabis or alcohol.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Generally, you should be <\/span><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/drugs-wellbutrin-interactions#wellbutrin-and-other-medications\"><span style=\"font-weight: 400;\">particularly careful about<\/span><\/a><span style=\"font-weight: 400;\"> combining Wellbutrin with other antidepressant drugs, monoamine oxidase inhibitors (MAOIs), and heavy alcohol intake.\u00a0<\/span><\/p>\n<hr \/>\n<p><i>Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.<\/i><\/p>\n<p><em>This article was first published on December 22, 2022, and updated in October 2024.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Have you ever considered using cannabis to treat your depression? If so, you\u2019re not alone. In fact, a growing number of people are turning to this herbal remedy to help improve their mood.\u00a0 But if you\u2019re taking the antidepressant\u00a0Wellbutrin (bupropion), is it\u00a0safe to use cannabis at the same time? Here are some facts you should&#8230;<\/p>\n","protected":false},"author":84,"featured_media":36722,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[254,259],"tags":[8473,13629,2261,13630,13628],"class_list":["post-25391","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle","category-research","tag-antidepressants","tag-bupropion","tag-depression","tag-mixing-cannabis-and-wellbutrin","tag-wellbutrin"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cannabis Central<\/title>\n<meta name=\"description\" content=\"Find out whether it&#039;s safe to use cannabis while being on Wellbutrin, and how the combination of these two medications work together.\" \/>\n<meta name=\"robots\" content=\"index, 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