{"id":25749,"date":"2025-01-23T08:00:45","date_gmt":"2025-01-23T13:00:45","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=25749"},"modified":"2025-01-22T11:47:33","modified_gmt":"2025-01-22T16:47:33","slug":"how-targeting-the-endocannabinoid-system-can-help-treat-borderline-personality-disorder","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/how-targeting-the-endocannabinoid-system-can-help-treat-borderline-personality-disorder\/","title":{"rendered":"How Targeting the Endocannabinoid System Can Help Treat Borderline Personality Disorder"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cannabis is known to help patients with a wide variety of health concerns and conditions, including different mental health issues. <\/span><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8033970\/#:~:text=This%20opens%20new,BPD%20is%20warranted.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recent studies<\/span><\/a><span style=\"font-weight: 400;\">, cannabis can offer symptom relief and management solutions for one such mental illness: borderline personality disorder (BPD).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In this article, you\u2019ll discover how BPD affects the body and how cannabis targets the endocannabinoid system (ECS) to offer those affected by this condition numerous symptomatic benefits.<\/span><\/p>\n<h2><strong>What is Borderline Personality Disorder (BPD)?\u00a0<\/strong><\/h2>\n<p><a href=\"https:\/\/www.nimh.nih.gov\/health\/topics\/borderline-personality-disorder\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Borderline personality disorder (BPD)<\/span><\/a><span style=\"font-weight: 400;\"> is a mental condition that results in people who have it struggling with difficulty managing emotions, relationships, and how they perceive themselves overall.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Millions of American adults suffering from BPD struggle with fluctuations in their mood, along with unstable thoughts, feelings, and behaviors.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common challenges for people with BPD include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Maintaining healthy relationships<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fear of abandonment\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intense, unstable emotions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Impulsive behavior<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty controlling anger, irritability, worry, or sadness (neuroticism)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Frequent self-image issues<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stress-related paranoia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cognitive distortions and dissociation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe functional impairments, like decision-making and long-term planning<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Self-harming behavior, including <\/span><a href=\"https:\/\/www.nimh.nih.gov\/health\/topics\/borderline-personality-disorder#:~:text=borderline%20personality%20disorder.-,Find%20help%20and%20support,chat%20at%20988lifeline.org%20.%20In%20life%2Dthreatening%20situations%2C%20call%20911.,-Additional%20federal%20resources\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">suicidal thoughts and attempts<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">While treatment options for BPD are limited, it can be managed in several ways. Some of the treatment options include therapy, help from healthcare providers, medications (e.g., antipsychotics, mood stabilizers, dietary supplements, antidepressants), and utilizing family and friends as a support system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More recently, patients have also found relief from BPD symptoms as a result of cannabis and the way it affects the brain.\u00a0\u00a0<\/span><\/p>\n<h3><b>Brain Areas Affected by Borderline Personality Disorder<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The brain areas that BPD typically impacts include the limbic system and prefrontal cortex, showing dysfunction between their connections. This contributes to the emotional dysregulation in BPD.\u00a0<\/span><span style=\"font-weight: 400;\">These brain regions are primarily involved with, and regulate, impulse control, emotions, and decision-making.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Research suggests certain hormonal, neurotransmitter, and endocannabinoid imbalances in the brain are observed in BPD patients. These imbalances, such as <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/what-is-anandamide\/\"><span style=\"font-weight: 400;\">anandamide<\/span><\/a><span style=\"font-weight: 400;\">, may also play a role in BPD symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because these various brain regions and endocrinology are disrupted, treating these areas of the brain can help people significantly with BPD.<\/span><\/p>\n<h2><b>Understanding the Endocannabinoid System (ECS)\u00a0<\/b><\/h2>\n<p><span style=\"box-sizing: border-box; margin: 0px; padding: 0px;\">The\u00a0<a href=\"https:\/\/www.veriheal.com\/blog\/cannabinoids-and-the-endocannabinoid-system-a-match-made-in-heaven\/\" target=\"_blank\" rel=\"noopener\">endocannabinoid system (ECS)<\/a> regulates bodily processes such as appetite, fat storage, and balance. <\/span><span style=\"font-weight: 400;\">It also affects mental processes like motivation, mood, memory, and cognition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The ECS works by controlling the communication between cells. They release molecules called endocannabinoids, which interact with two receptors: cannabinoid type-1 (CB1) and cannabinoid type-2 (CB2).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CB1 receptors are primarily found throughout the brain and nervous system, while CB2 receptors are found throughout the immune system. CB1 receptors involve mood regulation, memory, and cognitive function.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Once bound to their respective receptors, cannabinoids regulate biochemical reactions such as pain sensation and regulation, inflammation, neuroplasticity, and more.<\/span><\/p>\n<h2><b>How Cannabis Can Help With BPD\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Because<\/span> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8033970\/#:~:text=Endocannabinoid%20tone%20in,the%20BPD%20population.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recent research<\/span><\/a><span style=\"font-weight: 400;\"> shows that high levels of CB1 receptors exist in the same major brain areas associated with BPD, cannabinoids offer a promising treatment for this condition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No other pharmacological treatment for BPD has yet to achieve long-term success for those seeking relief from symptoms associated with BPD. <\/span><span style=\"font-weight: 400;\">However, cannabis might be the answer for those struggling with BPD symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mood regulation is crucial for people with BPD, and the endocannabinoid system uses cannabinoids and CB1 receptors to help balance out these mood imbalances and improve mood overall.\u00a0\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-022-04789-9#Sec8:~:text=Overall%2C%20this%20research,and%20BPD%20participants.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Preliminary studies<\/span><\/a><span style=\"font-weight: 400;\"> also suggest cannabis can help alleviate symptoms like anger, irritability, depression, anger, anxiety, sleep disturbances, and suicidal thoughts.<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-022-04789-9#Sec8:~:text=Overall%2C%20this%20research,and%20BPD%20participants.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Cannabidiol (CBD) specifically lowers FAAH<\/span><\/a><span style=\"font-weight: 400;\"> (an ECS enzyme) and increases anandamide (AEA), which activates endocannabinoid receptor CB1. CBD works directly on 5-HT1A serotonin receptors.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Anandamide and serotonin are known as \u201chappy chemicals\u201d in the body, which is why CBD can be so helpful with mood imbalance and depression.\u00a0\u00a0<\/span><\/p>\n<h2><b>What Type of Cannabis is Best for BPD?\u00a0\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">A treatment ratio of high levels of cannabinoids like cannabidiol (CBD) and a lower level of THC <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8033970\/#:~:text=The%20anxiolytic%2Dlike,for%20CBD%20features.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">is suggested<\/span><\/a><span style=\"font-weight: 400;\"> to have the most effective results for BPD so far.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/types-of-thc\/\"><b>Tetrahydrocannabinol (THC)<\/b><\/a><span style=\"font-weight: 400;\">\u00a0is the psychoactive cannabinoid responsible for inducing the \u201chigh\u201d, but also anxiety and paranoia, associated with marijuana use. Common THC therapeutic properties include appetite stimulation, anxiety relief, pain relief, and nausea reduction.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/cbd\/\"><b>Cannabidiol (CBD)<\/b><\/a><span style=\"font-weight: 400;\">\u00a0is a non-impairing cannabinoid known for its anti-inflammatory, anti-anxiety, and antipsychotic properties. By decreasing FAAH activity and increasing endocannabinoids like AEA, CBD is more helpful for BPD.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Overall, it\u2019s recommended to find a strain or hemp products higher in CBD and lower in THC since THC has a higher chance of causing an anxiogenic reaction, meaning something that causes fear or anxiety, in these BPD patients.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The low-THC to high-CBD ratio typically balances out cannabis features in the best way for those with BPD.<\/span><\/p>\n<h2><b>What Strains of Weed and Terpenes Are Best For BPD?\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Some specific strains of weed are optimal for those with BPD because of their THC and CBD ratios, along with the other terpenes and cannabinoids they possess.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That doesn\u2019t mean those suffering from BPD haven\u2019t found strains higher in THC and lower in CBD that have helped them. There isn\u2019t any evidence specifically on cultivars (strains) for BPD, but sativa strains may be best fit for those with BPD during daytime use, as they boost your mood and help ease anxiety.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, some people with BPD use an Indica-dominant strain at night specifically to help calm the mind and help them sleep.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Many strains these days are hybrids, though, so it\u2019s best to journal your experiences with different strains \u2013 or better yet, try <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/whats-the-difference-between-hemp-and-marijuana\/\"><span style=\"font-weight: 400;\">hemp products<\/span><\/a><span style=\"font-weight: 400;\"> rich in CBD, <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/what-are-the-therapeutic-benefits-of-cbda\/\"><span style=\"font-weight: 400;\">CBDA<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/what-you-should-know-about-cbg-and-its-health-benefits\/\"><span style=\"font-weight: 400;\">CBG<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Considering<\/span> <span style=\"font-weight: 400;\">the <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/\"><span style=\"font-weight: 400;\">terpenes within the cannabis strain<\/span><\/a><span style=\"font-weight: 400;\"> that might help alleviate symptoms associated with BPD is also important.<\/span><\/p>\n<p>Terpenes are aromatic compounds that naturally occur in cannabis plants. When consumed, they create a signature scent, flavor, and compound that has therapeutic benefits. <span style=\"font-weight: 400;\">Many studies have indicated that terpenes have the potential to help relieve stress, anxiety, and inflammation, as well as other properties like anxiolytic and sedative effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These terpene aroma profiles may also be used as aromatherapy to further help induce relaxation, uplift mood, or improve focus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of the terpenes that can help alleviate common BPD symptoms are:<\/span><\/p>\n<ul>\n<li><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/myrcene\/\"><span style=\"font-weight: 400;\">Myrcene<\/span><\/a><span style=\"font-weight: 400;\">: Relieves inflammation, pain, and insomnia. Strains that are high in myrcene include <\/span><a href=\"https:\/\/www.marijuanadoctors.com\/weed-101\/strains\/og-kush-cannabis-strain\/?seg_id=01JD00ZP15ZAHRPXNBPXZH3YPT.13780.1732724557380\"><span style=\"font-weight: 400;\">OG Kush<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.marijuanadoctors.com\/weed-101\/strains\/ac-dc-cannabis-strain\/?seg_id=01JD00ZP15ZAHRPXNBPXZH3YPT.13780.1732724557380\"><span style=\"font-weight: 400;\">ACDC<\/span><\/a><span style=\"font-weight: 400;\">, Purple Urkle, Critical Mass, and Granddaddy Purple. You can also look for strains like <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/chem-dawg-strain-review-a-potent-sativa-leaning-hybrid\/\"><span style=\"font-weight: 400;\">Chemdog<\/span><\/a><span style=\"font-weight: 400;\">, Sour Diesel, Girl Scout Cookies, Cookies and Cream, and Death Star.<\/span><\/li>\n<li><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/caryophyllene\/\"><span style=\"font-weight: 400;\">Caryophyllene<\/span><\/a><span style=\"font-weight: 400;\">: Relieves anxiety, depression, stress, inflammation, and pain. Popular strains that are high in this terpene include <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/chem-dawg-strain-review-a-potent-sativa-leaning-hybrid\/\"><span style=\"font-weight: 400;\">Chemdog<\/span><\/a><span style=\"font-weight: 400;\">, Sour Diesel, Girl Scout Cookies, Cookies and Cream, and Death Star.<\/span><\/li>\n<li><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/limonene\/\"><span style=\"font-weight: 400;\">Limonene<\/span><\/a><span style=\"font-weight: 400;\">: Stress reducer, anti-depressant, and anxiety reducer. Popular strains that are high in limonene include Lemon OG, Trainwreck, Durban Poison, Bruce Banner, Sour Diesel, and OG Kush.<\/span><\/li>\n<li><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/linalool\/\"><span style=\"font-weight: 400;\">Linalool<\/span><\/a><span style=\"font-weight: 400;\">: Relieves anxiety, stress, inflammation, insomnia, and pain. Popular strains that are high in this terpene include Amnesia Haze, Lavender Kush, Granddaddy Purple, and Purple Urkle.<\/span><\/li>\n<li><a href=\"https:\/\/www.veriheal.com\/blog\/terpenes\/pinene\/\"><span style=\"font-weight: 400;\">Pinene<\/span><\/a><span style=\"font-weight: 400;\">: Pinene can help boost energy levels, improve mental focus, reduce inflammation, and counter short-term memory loss, as well as being antiseptic and antiviral among other benefits. Popular strains high in this terpene include Bubba Kush, Dutch Treat, <\/span><a href=\"https:\/\/www.marijuanadoctors.com\/weed-101\/strains\/blue-dream-3-cannabis-strain\/?seg_id=01JD00ZP15ZAHRPXNBPXZH3YPT.13780.1732724557380\"><span style=\"font-weight: 400;\">Blue Dream<\/span><\/a><span style=\"font-weight: 400;\">, Jack Herer, and Harlequin.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Strains with a combination of the terpenes listed above that complement BPD symptom relief in high levels can be helpful.<\/span><\/p>\n<h2><b>Does CBD Without THC Help BPD?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">CBD products made from, or with, hemp oil without THC might also benefit those struggling with BPD.<\/span><\/p>\n<p><span style=\"box-sizing: border-box; margin: 0px; padding: 0px;\">Hemp oil is high in cannabinoids, terpenes, essential minerals, and\u00a0<a href=\"https:\/\/www.hsph.harvard.edu\/nutritionsource\/what-should-you-eat\/fats-and-cholesterol\/types-of-fat\/omega-3-fats\/\" target=\"_blank\" rel=\"noopener\">omega-3 fatty acids<\/a>. These compounds could have additional anti-inflammatory effects on the brain and help with cognitive function.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As previously mentioned, CBD increases endocannabinoids and helps with overactive neural health, mood, and communication.\u00a0 It also helps improve serotonin levels, which further helps improve mood, in addition to increasing AEA.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This helps with symptoms such as anger, anxiety, paranoia, and impulse control.<\/span><\/p>\n<h2><b>Final Thoughts\u00a0<\/b><b>\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Thanks to recent research and cannabis becoming better known for its medicinal properties, those suffering from borderline personality disorder might find relief from this incredible plant. <\/span><span style=\"font-weight: 400;\">The way cannabis, particularly CBD, boosts the endocannabinoid system is a game-changer for those with BPD because of how it affects the mind and relieves their symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some strains, terpenes, and ratios of THC and CBD need to be explored and tested for individuals with BPD to see what works best for them.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Conventional psychiatric treatments typically fail to show long-lasting improvements for BPD patients. However, many people have already found relief using weed to help them with their symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cannabis has offered hope to those fighting BPD who have yet to find relief through these conventional treatment methods.\u00a0<\/span><\/p>\n<hr \/>\n<p><i><span style=\"font-weight: 400;\">Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.<\/span><\/i><\/p>\n<p><em>This article was originally written by Lemetria Whitehurst in 2023 and updated in January 2025.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cannabis is known to help patients with a wide variety of health concerns and conditions, including different mental health issues. According to recent studies, cannabis can offer symptom relief and management solutions for one such mental illness: borderline personality disorder (BPD). In this article, you\u2019ll discover how BPD affects the body and how cannabis targets&#8230;<\/p>\n","protected":false},"author":99,"featured_media":37749,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[259],"tags":[13674,13675,12852,3164,61,84,136,4186,13029],"class_list":["post-25749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-borderline-personality-disorder","tag-bpd","tag-cannabis-therapy","tag-cannabis-treatment","tag-cbd","tag-endocannabinoid-system","tag-medical-cannabis","tag-mental-health","tag-mental-illness"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Using Cannabis to Help Treat Borderline Personality Disorder<\/title>\n<meta name=\"description\" content=\"Learn 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