{"id":27076,"date":"2023-06-28T08:30:56","date_gmt":"2023-06-28T12:30:56","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=27076"},"modified":"2026-03-23T07:35:00","modified_gmt":"2026-03-23T11:35:00","slug":"cbdv-a-comprehensive-guide-exploring-the-extensive-healing-potential-of-this-rare-cannabinoid","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/cbdv-a-comprehensive-guide-exploring-the-extensive-healing-potential-of-this-rare-cannabinoid\/","title":{"rendered":"CBDV: A Comprehensive Guide Exploring the Extensive Healing Potential of This Rare Cannabinoid"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">You\u2019ve heard of CBD (cannabidiol) and maybe even CBG (cannabigerol)\u2014but what about <\/span><a href=\"https:\/\/go.drugbank.com\/drugs\/DB14050\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBDV (cannabidivarin)<\/span><\/a><span style=\"font-weight: 400;\">? Often an overlooked cannabinoid, <\/span><span style=\"font-weight: 400;\">CBDV<\/span><span style=\"font-weight: 400;\"> has resurfaced as a valuable focus for the cannabis research community and was recently discussed during a <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=7_vR1vU8n4I\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">fascinating interview<\/span><\/a><span style=\"font-weight: 400;\"> with Veriheal <a href=\"https:\/\/www.veriheal.com\/personalized-cannabis-consultation\/\">cannabis coach<\/a> and medical expert\u00a0<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/authors\/abraham-benavides\/\"><span style=\"font-weight: 400;\">Dr. Abraham Benavides<\/span><\/a><span style=\"font-weight: 400;\">. From potential benefits for Autism Spectrum Disorder (ASD) and various inflammatory diseases to soothing anxiety, many promising therapeutic opportunities may arise from further investigations into this compound.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, before diving into the therapeutic applications of CBDV, it&#8217;s essential to understand what this unique cannabinoid is and how it differs from its well-known counterparts, CBD and THC.<\/span><\/p>\n<h2>What Is CBDV?<\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/go.drugbank.com\/drugs\/DB14050\" target=\"_blank\" rel=\"noopener\">Cannabidivarin (CBDV)<\/a> is a naturally occurring, rare compound in cannabis plants. Like CBD, it&#8217;s a non-intoxicating phytocannabinoid with a similar molecular structure. First isolated in 1969, CBDV typically occurs in higher concentrations in CBD-dominant, low-THC strains.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As Dr. Benavides explains, CBDV belongs to a group of &#8220;varin&#8221; cannabinoids that have two fewer carbon atoms compared to their non-varin counterparts. This structural difference imparts unique properties to these varin cannabinoids. When discussing the stark differences between the makeup of CBD vs. CBDV, Dr. Benavides stated, \u201cIf you\u2019ve studied organic chemistry, you would know that even just one atom\u2014or one atom in a different place\u2014makes an entire world of difference.\u201d<\/span><\/p>\n<h2>Here\u2019s What the Latest Scientific Research Says About CBDV<\/h2>\n<p><span style=\"font-weight: 400;\">The latest scientific research on CBDV sheds light on its unique interaction with the <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cannabinoids-and-the-endocannabinoid-system-a-match-made-in-heaven\/\"><span style=\"font-weight: 400;\">endocannabinoid system (ECS)<\/span><\/a><span style=\"font-weight: 400;\">, a complex cell-signaling network that maintains balance and homeostasis within the body. There are two primary receptors in the ECS:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">CB1: primarily found in the brain and central nervous system, where it regulates pain, inflammation<\/span><i><span style=\"font-weight: 400;\">,<\/span><\/i><span style=\"font-weight: 400;\"> nausea, and seizures. Additionally, cannabinoids work in this area to offer neuroprotection.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">CB2: predominantly located in the immune system and peripheral tissues (arms and legs), working primarily as an anti-inflammatory. <\/span><span style=\"font-weight: 400;\">Both receptors may have <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7037210\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">anticancer<\/span><\/a><span style=\"font-weight: 400;\"> effects.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Recent research has revealed that CBDV targets various specific receptors in the body, contributing to overall health and well-being. These receptors play a crucial role in various physiological processes, and CBDV&#8217;s interaction with them opens up a range of potential therapeutic applications. Let&#8217;s explore them in depth.<\/span><\/p>\n<h3><b>Transient Receptor Potential (TRP) Receptors<\/b><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6038138\/#:~:text=Transient%20Receptor%20Potential%20(TRP)%20channels%20are%20evolutionarily%20conserved%20integral%20membrane,6.1).\" target=\"_blank\" rel=\"noopener\">Transient receptor potential (TRP) receptors<\/a> are a family of ion channels that play crucial roles in sensing temperature, pressure, and chemical stimuli, contributing to various physiological processes in the body. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30697147\/\" target=\"_blank\" rel=\"noopener\">CBDV&#8217;s interaction with these receptors<\/a> may help alleviate chronic inflammatory and neuropathic pain, intestinal inflammation, nausea, seizures, and itching.<\/p>\n<h3><b>G Protein-Coupled Receptors (GPRs)<\/b><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7790836\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">G Protein-Coupled Receptors (GPRs) <\/span><\/a><span style=\"font-weight: 400;\">are a large family of cell surface receptors that detect external signals and trigger cellular responses, playing a vital role in various physiological processes and cellular communication. <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21907912\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research shows<\/span><\/a><span style=\"font-weight: 400;\"> CBDV targets GPRs, including GPR55 and GPR6.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">By targeting GPR55, CBDV may help mitigate chronic inflammatory and neuropathic pain. As it interacts with GPR6, it may have anti-proliferative and cancer-fighting properties, as it may block cell cycles that are &#8220;going bad.&#8221;<\/span><\/p>\n<h3><b>Dopamine Receptors\u00a0<\/b><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535451\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Dopamine<\/span><\/a><span style=\"font-weight: 400;\"> is a neurotransmitter in the brain that plays a vital role in regulating mood, motivation, reward, movement, and cognitive functions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The way CBDV interacts with <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28965530\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">dopamine-2 receptors<\/span><\/a><span style=\"font-weight: 400;\"> may offer significant therapeutic advantages, given that these receptors are involved in processes such as learning, memory, emotion, cognition, and movement. Since dopamine levels are affected in various conditions, including Alzheimer&#8217;s, Parkinson&#8217;s, neuropathic pain, epilepsy, anxiety, schizophrenia, and mood disorders, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33097185\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBDV&#8217;s influence on dopamine receptors<\/span><\/a><span style=\"font-weight: 400;\"> holds substantial potential for treatment.<\/span><\/p>\n<h3><b>GABA Receptors<\/b><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526124\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GABA (gamma-aminobutyric acid)<\/span><\/a><span style=\"font-weight: 400;\"> is an inhibitory neurotransmitter in the central nervous system that helps regulate neuronal excitability and plays a critical role in reducing anxiety and promoting relaxation. CBDV has been observed to interact with GABA receptors, potentially helping to alleviate seizures and anxiety. While the exact antiseizure and anticonvulsant mechanisms behind CBDV&#8217;s influence on GABA receptors remain unclear, this area of study presents an exciting avenue for continued research.<\/span><\/p>\n<h2>The Impact of CBDV on Certain Prescribed Medications<\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Benavides highlighted CBDV&#8217;s interaction with key enzymes in the body. He emphasized that <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24667653\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBDV is an inhibitor of CYP450 and CYP1A1 enzymes<\/span><\/a><span style=\"font-weight: 400;\">, which play crucial roles in breaking down medications. Dr. Benavides explained, &#8220;CYP450 is involved in breaking down around 90% of all prescribed medications, and so this is not something that can necessarily be overlooked.&#8221; He elaborated on the CYP450&#8217;s significance, stating that it is part of a &#8220;superfamily&#8221; of enzymes responsible for breaking down essential medicines, including blood thinners like warfarin, antidepressants, statins, and antiepileptic medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although CBDV&#8217;s inhibition of these enzymes may be less potent than CBD, it is still essential to consider the potential impact on other medications. Dr. Benavides clarified that the clinical significance of CBDV&#8217;s effects on raising medication levels might not be substantial, but caution is necessary when dealing with specific medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/gwcim.com\/people\/mikhail-kogan-md\/\" target=\"_blank\" rel=\"noopener\">Dr. Mikhail Kogan<\/a>, the interview host and medical director from the George Washington Center for Integrative Medicine, added valuable insights to the discussion. He explained that the method of administration, such as <\/span><a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sublingual-route\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">taking CBDV sublingually<\/span><\/a><span style=\"font-weight: 400;\"> (under the tongue), could significantly reduce the risk of interactions with medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Kogan explained, &#8220;this is important because we think that if you take CBD and CBDV and all these molecules under the tongue, and very little gets swallowed, that impact on the liver is very minimal because of the so-called lack of <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31869143\/#:~:text=The%20first%20pass%20effect%20is,action%20or%20the%20systemic%20circulation.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">&#8220;first pass effect.&#8221;<\/span><\/a><span style=\"font-weight: 400;\">\u00a0We like to give things under the tongue because that almost completely nullifies this possibility of interaction.&#8221;\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">By considering the nuances of CBDV&#8217;s interaction with essential enzymes and the mode of administration, users can make informed decisions about incorporating CBDV into their wellness routines.<\/span><\/p>\n<h2>What Is the Potential Clinical Significance of CBDV?<\/h2>\n<p><span style=\"font-weight: 400;\">Continuing the discussion, Dr. Benavides elaborated upon the potential clinical significance of CBDV, exploring its promising therapeutic applications related to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Autism Spectrum Disorder (ASD)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Duchenne Muscular Dystrophy (DMD)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Ulcerative Colitis (UC) and Inflammation Bowel Disorders (IBD)<\/span><\/li>\n<\/ul>\n<h3>Seizures<\/h3>\n<p><span style=\"font-weight: 400;\">The potential clinical significance of CBDV is underscored by its approved use in <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32103958\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">treating seizure-related disorders<\/span><\/a><span style=\"font-weight: 400;\">. The European Medicines Agency approved CBDV as a treatment for <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6696797\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Rett Syndrome<\/span><\/a><span style=\"font-weight: 400;\"> in 2017 and <\/span><a href=\"https:\/\/fragilex.org\/understanding-fragile-x\/info-series\/fragile-x-info-series-seizures\/#:~:text=Frequency,%2C%20and%206.2%25%20in%20females.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fragile X Syndrome<\/span><\/a><span style=\"font-weight: 400;\"> in 2018, thanks to its demonstrated anti-seizure properties. This achievement was made possible by <\/span><span style=\"font-weight: 400;\">GW Pharmaceuticals<\/span><span style=\"font-weight: 400;\">, the creators of Epidiolex, a CBD-based epilepsy drug approved in the United States.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Promising <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33895189\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">pre-clinical studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown that <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33920188\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBDV possesses anticonvulsant properties<\/span><\/a><span style=\"font-weight: 400;\">, and when combined with CBD, the compound&#8217;s anticonvulsant effects were amplified. In fact, the treatment group that received CBDV experienced a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33895189\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">40% decrease in seizures<\/span><\/a><span style=\"font-weight: 400;\">. However, further research is necessary to fully understand the precise mechanism behind this remarkable outcome.<\/span><\/p>\n<h3>Autism Spectrum Disorder<\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35320905\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research shows<\/span><\/a><span style=\"font-weight: 400;\"> that autism spectrum disorder (ASD) is characterized by lower levels of endocannabinoids. The prevailing theory suggests that supplementing with external phytocannabinoids <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6696797\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">could help restore balance<\/span><\/a><span style=\"font-weight: 400;\"> and <a href=\"https:\/\/www.veriheal.com\/blog\/cbdv-research-shows-a-strong-potential-for-autism-spectrum-disorder\/\" target=\"_blank\" rel=\"noopener\">improve ASD symptoms<\/a>.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A study involving mice with ASD induced by antiepileptic drugs found that CBDV administration restored much of the endocannabinoid signaling in their brains. This restoration was achieved by normalizing the levels of endocannabinoid enzymes, including CB1, and reducing neuroinflammation. As a result, the mice demonstrated noticeable improvements in several social and developmental areas, such as memory, cognition, social interactivity, and motor coordination. Their brain weight also returned to normal levels.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Currently, there are no drugs specifically targeting the core symptoms of ASD, so finding a treatment that can alleviate these symptoms is crucial. CBD and CBDV have now advanced to phase II randomized clinical trials and are actively recruiting participants for ASD studies.<\/span><\/p>\n<h3>Nausea<\/h3>\n<p><span style=\"font-weight: 400;\">Pre-clinical research has <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3792004\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">demonstrated CBDV&#8217;s potentia<\/span><\/a><span style=\"font-weight: 400;\">l to alleviate nausea in mice. Interestingly, CBDV works through a mechanism similar to THC but without causing intoxication. This unique property of CBDV presents a significant clinical advantage over traditional delta-9 THC, offering a non-intoxicating alternative for nausea relief.<\/span><\/p>\n<h3>Duchenne Muscular Dystrophy (DMD)<\/h3>\n<p><span style=\"font-weight: 400;\">In a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6487563\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2019 study<\/span><\/a><span style=\"font-weight: 400;\"> involving mice with DMD, CBDV administration led to improvements in muscle quality and movement. The compound slowed muscle degeneration and demonstrated remarkable anti-inflammatory and pro-autophagic effects, facilitating the breakdown of &#8220;sick cells.&#8221; Despite these promising findings, Dr. Benavides cautions that there is currently no clinical data on CBDV&#8217;s effects on DMD in humans, emphasizing the need for further research.<\/span><\/p>\n<h3>Ulcerative Colitis and Inflammatory Bowel Disorder<\/h3>\n<p><span style=\"font-weight: 400;\">The potential of CBDV in addressing ulcerative colitis (UC) and inflammatory bowel disorder (IBD) appears promising. Many UC patients have reported experiencing significant symptomatic relief when using medical cannabis, as documented in numerous surveys. CBDV has been found to <\/span><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/cn5000524\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">activate and desensitize TRPA1<\/span><\/a><span style=\"font-weight: 400;\">, a critical player in reducing intestinal inflammation. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Furthermore, researchers have discovered that CBDV can restore a healthier balance of gut bacteria by altering the dysregulation of gut microbiota. In an intriguing finding, colonic biopsies taken from pediatric patients with UC <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31553934\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">revealed a reduction in inflammatory cytokine expression<\/span><\/a><span style=\"font-weight: 400;\">, further supporting CBDV&#8217;s potential as an effective treatment for UC and IBD.<\/span><\/p>\n<h2>How to Find CBDV<\/h2>\n<p><span style=\"font-weight: 400;\">Finding CBDV can be relatively simple, as it originates from cannabis strains with a higher concentration of CBD. The easiest way to source CBDV is through reputable and licensed dispensaries or online retailers that sell CBDV-infused products such as oils, tinctures, capsules, creams, and edibles.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before purchasing any CBDV product, ensure that the manufacturer has conducted third-party lab testing and provides transparent information about the product&#8217;s composition and quality.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always consult a healthcare professional before incorporating CBDV into your wellness routine, especially if you are taking other medications or have existing health conditions.<\/span><\/p>\n<h2>Final Thoughts<\/h2>\n<p><span style=\"font-weight: 400;\">In conclusion, although rare, CBDV is a fascinating and promising cannabinoid that offers a wide range of potential therapeutic applications. From its potential benefits in managing epilepsy and autism spectrum disorders to its anti-inflammatory properties and possible neuroprotective effects, CBDV could be a game-changer in the world of natural remedies.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As scientists and healthcare professionals delve deeper into the world of CBDV, we may soon uncover even more groundbreaking discoveries that can improve the lives of countless individuals seeking relief and well-being through natural means.<\/span><\/p>\n<hr \/>\n<p><i><span style=\"font-weight: 400;\">Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>You\u2019ve heard of CBD (cannabidiol) and maybe even CBG (cannabigerol)\u2014but what about CBDV (cannabidivarin)? Often an overlooked cannabinoid, CBDV has resurfaced as a valuable focus for the cannabis research community and was recently discussed during a fascinating interview with Veriheal cannabis coach and medical expert\u00a0Dr. Abraham Benavides. From potential benefits for Autism Spectrum Disorder (ASD)&#8230;<\/p>\n","protected":false},"author":75,"featured_media":27992,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[259],"tags":[],"class_list":["post-27076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CBDV Benefits &amp; Healing Potential | Veriheal Guide<\/title>\n<meta name=\"description\" content=\"Explore the healing potential of CBDV with our comprehensive guide. Learn how this rare cannabinoid can benefit your health. 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