{"id":34617,"date":"2024-05-04T09:00:47","date_gmt":"2024-05-04T13:00:47","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=34617"},"modified":"2024-05-16T10:51:07","modified_gmt":"2024-05-16T14:51:07","slug":"cbd-vs-cbg","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/cbd-vs-cbg\/","title":{"rendered":"CBD vs. CBG: Benefits and Differences"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">As the narrative around cannabis evolves from stigma to solution, two leading players, <\/span><span style=\"font-weight: 400;\">CBD (cannabidiol)<\/span><span style=\"font-weight: 400;\"> and CBG (<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/what-you-should-know-about-cbg-and-its-health-benefits\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cannabigerol<\/span><\/a><span style=\"font-weight: 400;\">), are creating buzz without the euphoric \u201chigh.\u201d These non-psychoactive cannabinoids are reshaping our understanding of cannabis&#8217;s role in wellness.\u00a0<\/span><span style=\"font-weight: 400;\">So what exactly is CBG, and how does it differ from CBD? Let\u2019s look closer at the wonders of CBD vs. CBG, shedding light on their potential to revolutionize health care.<\/span><\/p>\n<h2>TLDR: CBD vs. CBG Differences and Benefits<\/h2>\n<ul>\n<li>CBG is the precursor to other cannabinoids like CBD, which is more prevalent and well-studied.<\/li>\n<li>CBD enhances endocannabinoids indirectly, while CBG interacts directly with CB1 and CB2 receptors.<\/li>\n<li>CBD is known for anti-inflammatory and neuroprotective properties, while CBG shows promise in neuroprotection and treating inflammatory diseases.<\/li>\n<li>CBD has extensive research support, whereas CBG is emerging with promising therapeutic effects.<\/li>\n<\/ul>\n<h2><strong>What is CBG?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">CBG, or cannabigerol<\/span><span style=\"font-weight: 400;\">, plays a pivotal role in the cannabis plant&#8217;s chemistry, often referred to as the \u2018starting point\u2019 of other cannabinoids. In the early stages of the plant&#8217;s growth, CBG is present as <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8669157\/#:~:text=CBGA%2C%20the%20precursor,9%2Dtetrahydrocannabinol.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cannabigerolic acid (CBGA)<\/span><\/a><span style=\"font-weight: 400;\">, the precursor from which other major and minor cannabinoids are synthesized.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Through enzyme processes, CBGA undergoes transformation, ultimately giving rise to the more familiar cannabinoids like CBD, THC, and CBC.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This unique position as a precursor makes CBG crucial in the cannabis plant&#8217;s development, which highlights its importance in the cannabis family tree. In addition, despite its conversion into other cannabinoids, CBGA itself <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8669157\/#:~:text=Cannabigerolic%20Acid%20CBGA,al.%2C%202017).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">offers potential health benefits<\/span><\/a><span style=\"font-weight: 400;\">. This makes understanding their role fascinating and vital for future research.<\/span><\/p>\n<h2><strong>The Science Behind CBD and CBG<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cannabinoids-and-the-endocannabinoid-system-a-match-made-in-heaven\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">endocannabinoid system (ECS)<\/span><\/a><span style=\"font-weight: 400;\"> plays a huge role in keeping balance in the human body, regulating functions such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immune function<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Cannabis contains <\/span><span style=\"font-weight: 400;\">over 120 cannabinoids<\/span><span style=\"font-weight: 400;\"> that influence the release of <\/span><span style=\"font-weight: 400;\">neurotransmitters<\/span><span style=\"font-weight: 400;\"> in the brain, hormones, and endocannabinoids and hit many non-cannabinoid receptors in the body. Two cannabinoid receptors are present in the ECS, with <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/cannabinoids-and-the-endocannabinoid-system-a-match-made-in-heaven\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CB1 and CB2<\/span><\/a><span style=\"font-weight: 400;\"> being the most significant.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CB1 receptors are primarily found in the brain and nervous system, influencing mood and cognition, while CB2 receptors are more common in the immune system, affecting inflammation and pain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CBD interacts indirectly with CB1 and CB2 receptors, not by binding directly to them, but by enhancing the body&#8217;s own endocannabinoids and influencing other receptors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In contrast, CBG directly interacts with both CB1 and CB2 receptors, albeit somewhat weakly.\u00a0<\/span><\/p>\n<h2><strong>What Are The Health Benefits of CBD?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">As arguably the most popular non-psychoactive cannabinoid present in cannabis, CBD has gained significant attention in the medical community for its many potential benefits, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anti-inflammatory properties<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Addiction treatment and smoking cessation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Epilepsy treatment<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potential benefits for neurodegenerative diseases<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety disorders<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Even though CBD doesn\u2019t act on CB1 or CB2, it has <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7796924\/#:~:text=Although%20direct%20effects,Kaplan%202020).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">over 65 other targets<\/span><\/a><span style=\"font-weight: 400;\"> in the body by which it can exert its anti-inflammatory, anti-addiction, neuroprotective, anticonvulsant, and immunomodulatory effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The best evidence for CBD comes from its <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7796924\/#:~:text=Epidiolex%C2%AE%20is%20the,unknown%20CBD%20bioavailability.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA trials and approval<\/span><\/a><span style=\"font-weight: 400;\"> in a purified pharmaceutical form called Epidiolex \u00ae. It is FDA-approved in children ages 1 year and up for seizures from rare childhood epileptic syndromes (e.g., Lennox-Gastaut, Dravet, and tuberous sclerosis complex.)\u00a0<\/span><\/p>\n<h2><strong>What Are The Health Benefits of CBG?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">CBG, though not as widely known, investigated, or abundant as CBD, has emerged with significant healing potential, including:<\/span><\/p>\n<h3><strong>Neuroprotective Properties <\/strong><\/h3>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9666035\/#:~:text=CBG%20is%20considered%20a%20partial,therapeutic%20approaches%20for%20several%20disorders.\" target=\"_blank\" rel=\"noopener\">CBG has possible neurological benefits<\/a> for various disorders due to its ability to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Protect neurons<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce brain inflammation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Promote cell repair<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This may help conditions like <\/span><a href=\"https:\/\/www.veriheal.com\/conditions\/huntington-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Huntington&#8217;s disease<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.veriheal.com\/conditions\/parkinsons-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Parkinson&#8217;s disease<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.veriheal.com\/conditions\/multiple-sclerosis\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">multiple sclerosis (MS)<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><strong>Anti-inflammatory Effects:<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">CBG&#8217;s interaction with the ECS could offer new treatment avenues for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/conditions\/inflammatory-bowel-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Inflammatory Bowel Disease (IBD)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/conditions\/crohns-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Crohn\u2019s Disease<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/conditions\/ulcerative-colitis\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ulcerative Colitis<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">By reducing gut inflammation and promoting the healing of intestinal cells, CBG could significantly improve the quality of life for people with symptoms of these debilitating conditions.<\/span><\/p>\n<h2><strong>What Are the Major Differences Between CBD vs. CBG?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">As interest in cannabinoid therapies grows, understanding the significant differences among CBD vs. CBG is crucial:<\/span><\/p>\n<h3><strong>Abundance<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">CBD is more commonly found in cannabis and is well-studied. On the flip side, CBG is somewhat rarer, comprising <\/span><span style=\"font-weight: 400;\">less than 1%<\/span><span style=\"font-weight: 400;\"> of most strains. This rareness is because CBGA is a precursor to other cannabinoids like CBD and THC. And plants tend to prefer going down one cannabinoid pathway or another.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, modern-day breeding techniques are able to give us type IV, or CBG-dominant, cannabis that is <\/span><a href=\"https:\/\/www.liebertpub.com\/doi\/10.1089\/can.2021.0058#:~:text=However%2C%20this%20situation%20changed%20with%20the%20development%20of%20plants%20expressing%20100%25%20of%20cannabinoid%20content%20as%20CBGA\/CBG%20through%20selective%20mendelian%20breeding%20of%20cannabis%20to%20eliminate%20enzymatic%20activity%20beyond%20CBGA.40%2C41\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">up to 100% CBG<\/span><\/a><span style=\"font-weight: 400;\">. So we could expect to see a flood of CBG products and research sooner rather than later.<\/span><\/p>\n<h3><strong>Research\u00a0<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">There is a wealth of research on CBD, highlighting its benefits for conditions such as epilepsy and anxiety. \u00a0 As mentioned above, CBD has achieved the gold standard of medical research \u2013 FDA approval for specific childhood seizure conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Conversely, CBG research is still technically in its infancy, but so far, it has indicated the possibility for neuroprotection, anti-inflammation, and antibacterial uses.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The first CBG clinical survey was published in 2023 by EB Russo. It <\/span><a href=\"https:\/\/www.liebertpub.com\/doi\/10.1089\/can.2021.0058#:~:text=Medicinal%20use%20of,for%20the%20condition.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">suggests significant symptomatic relief<\/span><\/a><span style=\"font-weight: 400;\"> for a variety of conditions. CBG was even reported as equal to or greater than conventional medications by patients.<\/span><\/p>\n<h3><strong>Effects on the Body<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">CBD influences the body indirectly, supporting the ECS without causing psychoactive effects. CBG, however, directly interacts with CB1 and CB2 receptors, suggesting reasons for its potent therapeutic effectiveness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, CBG and CBD have far-reaching effects on the rest of the body outside the ECS by interacting with key receptors in the <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/piecing-together-the-endocannabinoidome-charting-the-next-frontier\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">endocannabinoidome<\/span><\/a><span style=\"font-weight: 400;\">. Their direct actions on serotonin, TRP, GPR, and other pain-relieving and anti-inflammatory receptors and targets are critical to their therapeutic potential.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Overall, while CBD is widely recognized and researched, CBG still has a lot to offer with its unique features and prospective medical uses.<\/span><\/p>\n<h2><strong>CBD vs. CBG: The Bottom Line<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">In wrapping up our exploration of CBD vs. CBG, it&#8217;s clear these cannabinoids are more than just buzzwords in the natural health world. They offer a beacon of hope for various health concerns without the psychoactive effects traditionally associated with cannabis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Whether seeking relief from chronic conditions, or anxiety, or looking for a natural supplement, CBD and CBG present promising options. The future of these compounds is bright, as ongoing studies and growing acceptance pave the way for new therapeutic possibilities.<\/span><\/p>\n<h2>Frequently Asked Questions<\/h2>\n<h3>How does CBG make you feel?<\/h3>\n<p>CBG is thought to improve mental clarity and mood, as well as support energy and focus levels throughout the day.<\/p>\n<h3>Will CBG get you high?<\/h3>\n<p>No, CBG is a non-psychoactive cannabis compound that will not get you high.<\/p>\n<hr \/>\n<p><em><span style=\"font-weight: 400;\">Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before deciding on the treatment of a medical condition.<\/span><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As the narrative around cannabis evolves from stigma to solution, two leading players, CBD (cannabidiol) and CBG (cannabigerol), are creating buzz without the euphoric \u201chigh.\u201d These non-psychoactive cannabinoids are reshaping our understanding of cannabis&#8217;s role in wellness.\u00a0So what exactly is CBG, and how does it differ from CBD? Let\u2019s look closer at the wonders of&#8230;<\/p>\n","protected":false},"author":75,"featured_media":34673,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15362],"tags":[15072,16433,51,16432,84],"class_list":["post-34617","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-guides","tag-benefits-of-cbd","tag-benefits-of-cbg","tag-cannabinoid","tag-cbd-vs-cbg","tag-endocannabinoid-system"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cannabis Central<\/title>\n<meta name=\"description\" content=\"You&#039;ve probably heard of the cannabinoid CBD, but how familiar are you with CBG? 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