{"id":35867,"date":"2024-08-14T08:00:52","date_gmt":"2024-08-14T12:00:52","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=35867"},"modified":"2026-03-27T08:42:02","modified_gmt":"2026-03-27T12:42:02","slug":"is-kratom-safe","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/is-kratom-safe\/","title":{"rendered":"Is Kratom Safe? Exploring Kratom&#8217;s Effects on Brain, Traditional Uses &#038; Side Effects"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Kratom products have been increasing in popularity and availability across the United States in recent years, prompting questions about how safe kratom really is. About <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1403140\/full#:~:text=2.1%20Prevalence,Palamar%2C%202022).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1.7 million Americans<\/span><\/a><span style=\"font-weight: 400;\"> aged 12 and older reported using <a href=\"https:\/\/www.veriheal.com\/blog\/whats-all-the-hype-about-kratom\/\">kratom<\/a> in the most recent national drug survey in 2021, and the higher end of estimates reached about 10 million current users in 2019.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Many people report therapeutic benefits associated with the herbal drug, but other reports from medical authorities such as the US FDA, CDC, and the <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/prescription-drug-abuse\/in-depth\/kratom\/art-20402171\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mayo Clinic<\/span><\/a><span style=\"font-weight: 400;\"> caution against using kratom products.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here, we provide a balanced evaluation of the benefits and safety risks associated with using kratom and explore the effects of kratom on the body\u2019s biochemistry.\u00a0<\/span><\/p>\n<h2><b>What is Kratom?<\/b><\/h2>\n<p><a href=\"https:\/\/www.veriheal.com\/blog\/whats-all-the-hype-about-kratom\/\"><span style=\"font-weight: 400;\">Kratom<\/span><\/a><span style=\"font-weight: 400;\"> refers most generally to the <\/span><i><span style=\"font-weight: 400;\">Mitragyna speciosa<\/span><\/i><span style=\"font-weight: 400;\"> tree, indigenous to Southeast Asia. This tree belongs to the coffee family, and products made from its leaves have been used for <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/968786#:~:text=Kratom%20(Mitragyna%20speciosa%20Korth,thousands%20of%20years%20%5B4%5D.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">therapeutic applications and socioreligious ceremonies<\/span><\/a><span style=\"font-weight: 400;\"> in its native regions for centuries.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kratom use in the United States is comparatively new and did not become widespread <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2021.789075\/full#:~:text=Although%20use%20of,Walsh%2C%202018).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">until around 2015<\/span><\/a><span style=\"font-weight: 400;\">. Today, you can find various kratom products \u2014 which include loose leaf, powder, capsules, and concentrates \u2014 legally available for purchase through online retailers, smoke shops, convenience stores, and supplement purveyors across 46 states. Age restrictions may apply in some states, so always double-check your local laws.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The leaves of the kratom tree <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2021.751656\/full\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">contain over 40 alkaloids<\/span><\/a><span style=\"font-weight: 400;\">, with mitragynine and 7-hydroxymitragynine being the most pharmacologically significant. These compounds interact with mu-opioid receptors on nerve cells, inducing diverse effects that range from pain relief and energy stimulation to anxiety reduction and sleep improvement.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0376871620300144?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research analyzing self-reports<\/span><\/a><span style=\"font-weight: 400;\"> about kratom use in the US indicates that kratom is primarily self-administered for symptoms such as:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal effects in substance use disorders, p<\/span><span style=\"font-weight: 400;\">articularly in opioid weaning, withdrawal, and cravings<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Kratom is currently legal at the federal level and in most states. However, the emergence of poisoning cases involving kratom has aroused safety concerns, which have led the FDA and the Drug Enforcement Administration (DEA) to issue multiple warnings identifying kratom as a \u201cdrug of concern.\u201d The CDC and DEA have <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0376871617305586?via%3Dihub#:~:text=For%20example%2C%20the,Mallea%2C%202014).1\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">even explicitly warned<\/span><\/a><span style=\"font-weight: 400;\"> that kratom may cause psychosis or death.<\/span><\/p>\n<h2><b>Kratom and Health Benefits: Popular Uses and Scientific Evidence<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">People take Kratom to <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2021.789075\/full#:~:text=Exploratory%20surveys%20in,Walsh%2C%202018).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">relieve a variety of symptoms<\/span><\/a><span style=\"font-weight: 400;\">. With limited scientific research available to verify the effectiveness of Kratom for therapeutic uses, the benefits of kratom use are largely supplied by <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/968786\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">anecdotal reports<\/span><\/a><span style=\"font-weight: 400;\"> from individual users. Some users take kratom to self-treat:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Symptoms related to drug withdrawal, particularly from opioids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle cramps<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depressed mood<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low physical stamina and energy<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, these beneficial effects associated with kratom are yet to be legitimized by significant evidence from modern scientific studies. So, there is a level of caution that must be exercised when considering whether to give kratom a try, given that research on the effectiveness of kratom is still unfolding and the potential risks are significant.\u00a0<\/span><\/p>\n<h2><b>Potential Risks Associated with Kratom<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Because of the limited scientific research on kratom\u2019s benefits and side effects, it is unclear whether kratom will produce the desired effects it is reputed to provide \u2014 especially on the individual level. One must consider if the potential risks outweigh the possible benefits.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kratom may interact with certain medications in ways that have not yet been studied, and people with certain conditions may not respond well to taking kratom. Therefore, it is recommended that consumers consult with a physician regarding their personal medical history before approaching kratom as a potential treatment option, and never self-diagnose or self-treat.<\/span><\/p>\n<h3><b>Adverse Effects<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The adverse effects of kratom may not be worth the benefits associated with its use and can even be severe. <\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40122-020-00151-x\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Preclinical studies<\/span><\/a><span style=\"font-weight: 400;\"> on the physiological effects produced by kratom\u2019s most prominent alkaloid, mitragynine, have yielded some concerning results. For example, studies using mice and rats have pointed to the possibility that there may be a risk of addiction with kratom use, as well as cognitive impairment.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are also case studies that indicate the possibility that a range of organ systems may be susceptible to kratom-related damage. Examples include kidney injury, cardiotoxicity, thyroid damage, and hypothyroidism. Liver injury in particular appears to be an especially common reaction.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other adverse effects associated with kratom ingestion include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tachycardia (increased heart rate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypertension (high blood pressure)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aching muscles or joints<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It is important, however, to note that many of these negative outcomes are the result of chronic use or high doses of kratom. Additionally, more severe effects such as seizures, respiratory arrest, and death occurred in the <\/span><a href=\"https:\/\/academic.oup.com\/jat\/article\/43\/8\/615\/5550863\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">presence of other drugs<\/span><\/a><span style=\"font-weight: 400;\"> in the person\u2019s system and with incredibly high doses of kratom.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since kratom acts on mu-opioid receptors, the potential for harm, dependence, and withdrawal is still there. Like most drugs, <\/span><a href=\"https:\/\/academic.oup.com\/jat\/article\/43\/8\/615\/5550863#:~:text=The%20effects%20of,%CE%BC%2Dopioid%20receptor\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">kratom&#8217;s side effects are dose-dependent<\/span><\/a><span style=\"font-weight: 400;\">. So far, it seems low doses of 1-5 grams cause stimulant effects, while higher doses of 5-15 grams give stronger opioid-like effects. The safety of any kratom doses, frequency, and routes are unknown.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Thus, it\u2019s important to do more research into the toxicity profile, dosing, and potential therapeutic effectiveness \u2013 if any \u2013 for low to moderate doses of kratom. We need to understand the extent to which kratom might be harmful altogether, or just in cases of abuse.\u00a0<\/span><b><\/b><\/p>\n<h3><b>Lack of Regulatory Oversight<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Kratom\u2019s health applications are yet to be legitimized by the scientific community, so the <\/span><a href=\"https:\/\/www.fda.gov\/news-events\/public-health-focus\/fda-and-kratom#:~:text=There%20are%20no,7%2DOH%2Dmitragynine).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA has not approved Kratom<\/span><\/a><span style=\"font-weight: 400;\"> as a drug or supplement. This means that Kratom products are unregulated and are not held to any comprehensive, enforced standards.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So, like in the case of non-prescription CBD and hemp products, there is a level of caution consumers must exercise when selecting a particular brand or purveyor of kratom. With the lack of regulatory framework or enforcement in place, there can be kratom products that are falsely advertised, ineffective, or even unsafe. For example, in 2018, the FDA issued a mandatory recall due to Salmonella contamination in kratom products.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Moreover, the DEA has placed kratom on its Drugs and Chemicals of Concern list, although kratom is not yet considered to be a controlled substance.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The lack of control makes it difficult to ensure that consumers are receiving reliable information regarding their product\u2019s processing, dosing, or labeling, which adds further uncertainty regarding the health risks associated with consuming kratom products. Unfortunately, certain manufacturers may be adding much more kratom or adulterants to products than naturally available in the plant, increasing the risk of side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kratom is widely available online, in supplement stores, and even in gas stations and smoke shops across most of the US, except in states and cities where it is banned. Online retailers must often market kratom products as being &#8220;for soap-making and aromatherapy&#8221; to circumvent the 2014 FDA ban on the importation of kratom for use as a dietary supplement.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Therefore, it\u2019s important to seek out trustworthy brands and vendors (i.e. GMP certified) when purchasing kratom to be more confident that you are not receiving contaminated or falsely advertised products.<\/span><\/p>\n<h2><b>So, Is Kratom Safe?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Although kratom has been used for hundreds of years, there is still little modern scientific evidence supporting its touted benefits. Conversely, many studies are illuminating the possible toxic and adverse effects associated with kratom use, but most of these studies were done with animals and involved testing the effects of high doses of kratom or chronic kratom use. Since the absence of evidence does not necessarily indicate evidence of absence, kratom may provide desirable outcomes that have not been thoroughly researched yet, especially for those recovering from opioid addiction or individuals with chronic pain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Overall, the case for kratom is still under development, so it is recommended that consumers proceed with caution. Always consult a physician regarding choices that will affect your current healthcare plan, and research particular kratom brands and retailers carefully before making your kratom purchases. Remember that without clinical research, third-party testing, and regulations, none of these products can be guaranteed to be fully safe or pure.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kratom products have been increasing in popularity and availability across the United States in recent years, prompting questions about how safe kratom really is. About 1.7 million Americans aged 12 and older reported using kratom in the most recent national drug survey in 2021, and the higher end of estimates reached about 10 million current&#8230;<\/p>\n","protected":false},"author":84,"featured_media":35876,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[259],"tags":[16878,6863,16880,16882,16881,16877,16883,16879],"class_list":["post-35867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-is-kratom-safe","tag-kratom","tag-kratom-benefits","tag-kratom-research","tag-kratom-risks","tag-kratom-safety","tag-kratom-study","tag-kratom-uses"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is Kratom Safe? Effects, Uses and Side Effects<\/title>\n<meta name=\"description\" content=\"Is Kratom Safe? Explore the side effects, risks of overdose, and health benefits of Kratom. Learn about its uses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.veriheal.com\/blog\/is-kratom-safe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is Kratom Safe? Exploring Kratom&#039;s Effects on Brain, Traditional Uses &amp; Side Effects\" \/>\n<meta property=\"og:description\" content=\"Is Kratom Safe? Explore the side effects, risks of overdose, and health benefits of Kratom. 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