{"id":40195,"date":"2025-10-29T07:04:44","date_gmt":"2025-10-29T07:04:44","guid":{"rendered":"https:\/\/www.veriheal.com\/blog\/?p=40195"},"modified":"2025-10-29T07:04:44","modified_gmt":"2025-10-29T11:04:44","slug":"medications-to-avoid-mixing-with-cannabis","status":"publish","type":"post","link":"https:\/\/www.veriheal.com\/blog\/medications-to-avoid-mixing-with-cannabis\/","title":{"rendered":"12 Medications You Should Never Mix With Cannabis"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cannabis by itself poses very little to no risk to most people. But that changes when you incorrectly use it, and one of the most dangerous mistakes you can make is mixing cannabis with certain medications by yourself. Why? Some medications become toxic when used alongside cannabis, while others may lose their effectiveness, leaving your condition untreated.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To help you avoid using marijuana dangerously, we\u2019ve compiled a list of drugs you should never use alongside it on your own. Keep in mind that some might be combined only under medical supervision in special circumstances, but you should never adjust your own meds or start doing so on your own.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s the list:<\/span><\/p>\n<h2><b>1.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Blood Thinners<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Blood thinners or anticoagulants help prevent blood clots from forming or growing larger. They\u2019re typically prescribed to reduce the risk of strokes, heart attacks, and pulmonary embolisms caused by blood clots. However, <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/is-it-safe-to-mix-weed-with-blood-thinners\/\"><span style=\"font-weight: 400;\">mixing weed with blood thinners<\/span><\/a><span style=\"font-weight: 400;\"> can be risky. That\u2019s because THC and CBD, the two main cannabinoids (cannabis compounds), can interact with the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31724188\/#:~:text=Legalization%20of%20medical,and%20knowledge%20gaps.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">same liver enzymes<\/span><\/a><span style=\"font-weight: 400;\"> that process blood thinners and other medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These cannabinoids may slow down how quickly these enzymes break down blood thinners, leading to the medication staying in your system longer. This increases the medication\u2019s effect, putting you at risk of easy bruising or uncontrolled bleeding. It may also amplify common side effects of anticoagulants, such as dizziness, drowsiness, or confusion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Commonly prescribed anticoagulants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warfarin (Coumadin\u00ae, Jantoven\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clopidogrel (Plavix\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heparin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Apixaban (Eliquis\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dabigatran (Pradaxa\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rivaroxaban (Xarelto\u00ae)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A<\/span><a href=\"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2881\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">systematic review<\/span><\/a><span style=\"font-weight: 400;\"> suggests that heavy cannabis use may amplify warfarin&#8217;s anticoagulant effects. Another study supports this by showing that<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.13152\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">cannabis may slow warfarin\u2019s metabolism<\/span><\/a><span style=\"font-weight: 400;\">, leading to delayed blood clotting. Cumulative data show that there are <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31724188\/#:~:text=Components%20of%20medical,and%20knowledge%20gaps.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">several case reports<\/span><\/a><span style=\"font-weight: 400;\"> indicating higher warfarin levels in serum, higher INRs, and an increased risk of bleeding.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there is <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8744571\/#:~:text=Based%20on%20THC,nearly%20a%20year.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">contradictory evidence<\/span><\/a><span style=\"font-weight: 400;\"> from a case report where INR was not affected by daily cannabis use in an 85-year-old patient, indicating this is nuanced and not always straightforward. Also, recent research suggests that less than <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10824494\/#:~:text=Inhibited%20cytochrome%20P450,Measures%3A%20see%20above\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">30 mg of THC daily<\/span><\/a><span style=\"font-weight: 400;\"> may not cause significant interactions here, but <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10824494\/#:~:text=In%20addition%2C%20CBD%20increases%20the%20plasma%20concentrations%20of%20CYP3A4%20substrates%20such%20as%20warfarin%20or%20tacrolimus%20(23%2C%20e38).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBD might<\/span><\/a><span style=\"font-weight: 400;\"> anyway.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Speaking to your specialist first is best for their opinion and making informed decisions together. They will need to monitor your labs and adjust your doses of warfarin (by ~<\/span><a href=\"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2881#:~:text=Four%20cases%20involved%20reduction%20in%20weekly%20warfarin%20dose%20ranging%20from%2022%25%20to%2031%25.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">22-31%<\/span><\/a><span style=\"font-weight: 400;\">), cannabis, or both. You should never adjust or stop medications like blood thinners by yourself.<\/span><\/p>\n<h2><b>2.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Sedatives<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Prescription and over-the-counter (OTC) sedatives can help you sleep longer and better, at least in the short term. Most of them work by slowing brain activity and helping you relax. Many cannabinoids and terpenes can also have sedative and deep-sleep-promoting effects to help you sleep. As such, combining cannabis with sleeping aids can enhance the effects of both substances, potentially leading to excessive drowsiness, confusion, and impaired coordination.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The real danger lies in how these combined effects can severely impact your ability to function safely. When cannabis and sedatives amplify each other, your risk of accidents, falls, and even respiratory depression significantly increases. The danger is even higher in older adults or those with underlying health conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of prescription and OTC sleeping aids you should never mix on your own with cannabis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zolpidem (<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/is-it-safe-to-combine-weed-and-ambien\/\"><span style=\"font-weight: 400;\">Ambien<\/span><\/a><span style=\"font-weight: 400;\">\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eszopiclone (Lunesta\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zaleplon (Sonata\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diphenhydramine (Benadryl)\u00ae<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Doxylamine (Unisom\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Melatonin<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you have sleeping issues or have difficulty getting off of these medications, as many people do, your provider may be able to help you wean off of them using cannabis under their medical supervision.<\/span><\/p>\n<h2><b>3.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Benzodiazepines<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Benzodiazepines are central nervous system depressants that slow down activity in your brain. This effect can help reduce anxiety, promote sleep, and relax muscles, making them useful for treating conditions like insomnia, panic disorders, and seizures.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, mixing benzodiazepines with cannabis is potentially dangerous because both are central nervous system depressants. Their combined effects can amplify sedation, impair coordination, slow breathing, and increase the risk of <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7055953\/#:~:text=There%20are%20potential,when%20clinically%20feasible.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">accidents or overdose<\/span><\/a><span style=\"font-weight: 400;\">. The risk is even higher if you use benzodiazepines with high-THC cannabis, or if you are particularly sensitive to THC\u2019s effects.<\/span><\/p>\n<figure id=\"attachment_40196\" aria-describedby=\"caption-attachment-40196\" style=\"width: 866px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\" wp-image-40196\" src=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1295607003-612x612-1-300x200.jpg\" alt=\"benzodiazepine drug\" width=\"866\" height=\"577\" srcset=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1295607003-612x612-1-300x200.jpg 300w, https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1295607003-612x612-1.jpg 612w\" sizes=\"(max-width: 866px) 100vw, 866px\" \/><figcaption id=\"caption-attachment-40196\" class=\"wp-caption-text\">Source: iStock<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Benzodiazepines you shouldn\u2019t use with cannabis on your own include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/can-should-you-combine-xanax-alprazolam-and-cannabis\/https:\/www.veriheal.com\/blog\/can-should-you-combine-xanax-alprazolam-and-cannabis\/\"><span style=\"font-weight: 400;\">Alprazolam (Xanax\u00ae)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chlordiazepoxide (Librium\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clorazepate (Tranxene\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diazepam (Valium\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clobazam (Onfi\u00ae, Frisium\u00ae, Urbanol\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/cannabis-and-klonopin-a-dangerous-duo-or-magical-combo\/\"><span style=\"font-weight: 400;\">Clonazepam (Klonopin\u00ae)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lorazepam (Ativan\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oxazepam (Serax\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prazepam (Centrax\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quazepam (Doral\u00ae)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some epileptic patients, like those with <\/span><a href=\"https:\/\/www.veriheal.com\/conditions\/lennox-gastaut-syndrome\/\"><span style=\"font-weight: 400;\">Lennox-Gastaut Syndrome (LGS)<\/span><\/a><span style=\"font-weight: 400;\">, may need to stay on some of these medications, like clobazam or clonazepam, and still <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7821324\/#:~:text=Conclusions,CBD%20and%20clobazam.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">take their prescription CBD<\/span><\/a><span style=\"font-weight: 400;\">. Specialist consultation is necessary before starting cannabis to account for blood labs, monitor for reactions, and adjust these doses over time.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Your provider can also create a safe tapering plan if you have benzodiazepine dependence and want to <\/span><a href=\"https:\/\/bmcpublichealth.biomedcentral.com\/articles\/10.1186\/s12889-024-18356-6#Sec16:~:text=Conclusions,to%20benzodiazepine%20medication.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">wean using cannabis<\/span><\/a><span style=\"font-weight: 400;\">, an approach still being researched.<\/span><\/p>\n<h2><b>4.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>First-generation H1 Antihistamines<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019ve ever had the flu or allergies, you\u2019ve likely used an antihistamine. They are widely available and easily accessible as OTC meds, such as Benadryl\u00ae. There are also stronger, prescription-only antihistamines for treating severe itching, hives, hay fever, and migraines.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antihistamines are usually categorized as H1 or H2 blockers. H1 blockers are further divided into first-generation and second-generation allergy meds, while H2 antihistamines are used for acid reflux and stomach acid. First-generation H1 antihistamines can cross the blood-brain barrier and directly cause CNS-depressing side effects like drowsiness and brain fog \u2013 causing a potential interaction with cannabis \u2013 while second-gen and H2 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538188\/#:~:text=Indications-,Antihistamines%20are%20a%20pharmaceutical%20class%20of%20drugs%20that%20act%20to%20treat,1%20receptors%3B%20this%20leads%20to%20different%20therapeutic%20and%20side%20effect%20profiles,-.%5B2%5D\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">antihistamines work differently<\/span><\/a><span style=\"font-weight: 400;\"> and don\u2019t have the same side effects or significant interaction potential.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mixing first-generation, H1 OTC or prescription antihistamines with cannabis can cause excessive drowsiness, slowed breathing, and even respiratory depression. That\u2019s because the sedative and nervous system depressant effects of both substances can stack and overwhelm your body, making it harder to stay alert and breathe properly. High doses may lead to dangerously slow breathing, unconsciousness, and an increased risk of accidents or overdose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of first-gen, H1 antihistamines that don\u2019t interact well with cannabis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diphenhydramine (Benadryl\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hydroxyzine (Vistaril\u00ae, Atarax\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Promethazine (Phenergan\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chlorpheniramine (Chlor-Trimeton\u00ae, found in Tylenol\u00ae Cold\/Allergy and Diabetic Tussin\u00ae)<\/span><\/li>\n<\/ul>\n<h2><b>5.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Opioids<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Doctors typically prescribe opioids to help patients treat acute or chronic pain. The pain may be from surgery, injury, cancer, or long-term conditions like arthritis or back problems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Opioids typically treat pain by binding to opioid receptors in the brain, spinal cord, and other areas of the body. Doing so blocks pain signals, changing how the brain perceives pain. The medication may also make you feel euphoric and induce a sense of calm to distract you from pain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mixing such medications with cannabis is dangerous because their combined effects may intensify sedation, impair judgment, and dangerously slow breathing. Their stacked effects may also increase the risk of overdose, unconsciousness, and in severe cases, respiratory failure or death. As such, you shouldn\u2019t mix weed with opioids without your <\/span><a href=\"https:\/\/www.mayoclinicproceedings.org\/article\/S0025-6196(18)30709-2\/fulltext#:~:text=Certifying%20clinicians%20should,lengths%20for%20recertification.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">doctor\u2019s go-ahead and guidance<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<figure id=\"attachment_40202\" aria-describedby=\"caption-attachment-40202\" style=\"width: 855px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\" wp-image-40202\" src=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-832279584-612x612-1-300x200.jpg\" alt=\"Crushed powdered opioids in spoon with lighter, pills and syringe.\" width=\"855\" height=\"570\" srcset=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-832279584-612x612-1-300x200.jpg 300w, https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-832279584-612x612-1.jpg 612w\" sizes=\"(max-width: 855px) 100vw, 855px\" \/><figcaption id=\"caption-attachment-40202\" class=\"wp-caption-text\">Source: iStock<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Examples of opioids you shouldn\u2019t mix with cannabis without medical supervision include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oxycodone (OxyContin\u00ae, also found in <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/is-it-safe-to-mix-percocet-and-cannabis-exploring-the-effects\/\"><span style=\"font-weight: 400;\">Percocet<\/span><\/a><span style=\"font-weight: 400;\">\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hydrocodone (found in Vicodin\u00ae, Norco\u00ae, Lortab\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Morphine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/the-dangers-of-mixing-cannabis-and-codeine\/\"><span style=\"font-weight: 400;\">Codeine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/tramadol-and-cannabis-why-you-shouldnt-combine-the-two\/\"><span style=\"font-weight: 400;\">Tramadol<\/span><\/a><span style=\"font-weight: 400;\"> (Ultram<\/span><span style=\"font-weight: 400;\">\u00ae<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p style=\"text-align: center;\"><strong>READ: <a class=\"sc-keVmGr gFomhY\" href=\"https:\/\/www.veriheal.com\/blog\/what-are-the-risks-of-combining-cannabis-and-hydroxyzine\/\" target=\"_blank\" rel=\"noopener\">What Are the Risks of Combining Cannabis and Hydroxyzine?<\/a><\/strong><\/p>\n<h2><b>6.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Select Antidepressants<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Your prescribed antidepressants may be selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), atypicals (e.g., bupropion, mirtazapine, etc.), or monoamine oxidase inhibitors (MAOIs). While you may cautiously mix some of these classes of <\/span><a href=\"https:\/\/www.marijuanadoctors.com\/blog\/can-you-use-cannabis-while-taking-anti-depressants\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">antidepressants with marijuana <\/span><\/a><span style=\"font-weight: 400;\">under your doctor\u2019s guidance, TCAs and MAOIs pose the most risk with marijuana.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MAO inhibitors and weed may cause serious <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/serotonin-syndrome-unmasked-can-cannabis-and-psychedelics-trigger-this-mysterious-condition\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> \u2013 a potentially life-threatening condition caused by too much serotonin in the brain. Symptoms include confusion, rapid heart rate, high blood pressure, muscle rigidity, unconsciousness, and even seizures. TCAs, on the other hand, may dangerously sedate, especially at higher doses.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, don\u2019t underestimate SSRIs, SNRIs, and atypical depressants. When used with cannabis, they may <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8307883\/#sec4-jpm-11-00615:~:text=As%20THC%20and,concentrations%20%5B63%5D.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">intensify common side effects<\/span><\/a><span style=\"font-weight: 400;\"> like drowsiness, anxiety, dizziness, or mood swings. Cannabis may also interfere with how well these antidepressants work, but we don\u2019t have enough long-term studies yet.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Popular versions of these antidepressants include:<\/span><\/p>\n<h3><b>MAOIs<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phenelzine (Nardil\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tranylcypromine (Parnate\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Isocarboxazid (Marplan\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Selegiline (Emsam\u00ae)<\/span><\/li>\n<\/ul>\n<h3><b>TCAs<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amitriptyline (Elavil\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nortriptyline (Pamelor\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Imipramine (Tofranil\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clomipramine (Anafranil\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Desipramine (Norpramin\u00ae)<\/span><\/li>\n<\/ul>\n<h3><b>SSRIs<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluoxetine (<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/mixing-prozac-and-cannabis-know-the-dangers-and-benefits\/\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\">\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sertraline (Zoloft\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Citalopram (Celexa\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Escitalopram (Lexapro\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Paroxetine (Paxil\u00ae)<\/span><\/li>\n<\/ul>\n<h3><b>SNRIs<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Venlafaxine (Effexor\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Duloxetine (<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/is-it-safe-to-mix-cymbalta-and-weed\/\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a><span style=\"font-weight: 400;\">\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Desvenlafaxine (Pristiq\u00ae)<\/span><\/li>\n<\/ul>\n<h3><b>Atypical Antidepressants<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bupropion (Wellbutrin\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mirtazapine (Remeron\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trazodone (Desyrel\u00ae)<\/span><\/li>\n<\/ul>\n<h2><b>7.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Immunosuppressants<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Your doctor may prescribe an immunosuppressant to calm your immune system before or after an organ transplant, or more commonly to manage autoimmune diseases like lupus, rheumatoid arthritis, or Crohn\u2019s disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Using cannabis alongside such medications can be problematic because THC and CBD <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1282831\/full#:~:text=Given%20the%20metabolism,narrow%20therapeutic%20indices.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">interfere with CYP3A4<\/span><\/a><span style=\"font-weight: 400;\">, the liver enzyme that breaks down most immunosuppressants. This can make an immunosuppressant\u2019s active ingredients accumulate in your blood, <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1282831\/full#:~:text=Transplant%20medications%20(mTOR,adverse%20events%20(19.6%25).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increasing the risk of toxicity<\/span><\/a><span style=\"font-weight: 400;\"> and overdose. It can also compromise your treatment, raising the risk of infection, kidney damage, or <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/ctr.15264#:~:text=Conclusions,among%20cannabis%20users.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">organ rejection<\/span><\/a><span style=\"font-weight: 400;\"> (although data are weak).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Organ donors may also be sadly excluded or rejected simply due to cannabis use out of precaution.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of immunosuppressant drugs you should never mix with marijuana include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclosporine (Neoral\u00ae, Sandimmune\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sirolimus (Rapamune\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Everolimus (Zortress\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tacrolimus (Prograf\u00ae, Envarsus XR\u00ae)<\/span><\/li>\n<\/ul>\n<h2><b>8.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Anticonvulsants<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Cannabis, specifically CBD, can help <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33332006\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">treat various types of seizures<\/span><\/a><span style=\"font-weight: 400;\">. In fact, FDA-approved CBD medications like Epidiolex\u00ae are available for treating severe seizure disorders in children and adolescents.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, if you\u2019re already using prescription anticonvulsants for your seizures, you shouldn\u2019t use cannabis without your doctor\u2019s go-ahead. That\u2019s because CBD and other cannabinoids can interact with liver enzymes like<\/span><a href=\"https:\/\/emedicine.medscape.com\/article\/1187334-overview#showall:~:text=As%20with%20other,its%20active%20metabolite).\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">CYP3A4 and CYP2C19<\/span><\/a><span style=\"font-weight: 400;\">, which process most anticonvulsants. The interaction may cause the <\/span><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full\/10.1111\/cts.13812#:~:text=Evidence-,Antiepileptics,valproate%20may%20have%20to%20be%20discontinued%20due%20to%20their%20hepatotoxicity%20profile.,-Anti%2Dinfectives\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">medication to accumulate<\/span><\/a><span style=\"font-weight: 400;\"> in your system, increasing the risk of side effects, toxicity, or reduced seizure control.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In studies involving the use of <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1282831\/full#:~:text=We%20have%20identified,to%20adverse%20events.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CBD and anti-epileptic drugs<\/span><\/a><span style=\"font-weight: 400;\"> (AEDs) like valproate, several participants experienced adverse effects like rashes, fever, and liver enzyme elevation. Besides valproate (Depakene\u00ae), other anticonvulsants you shouldn\u2019t mix with cannabis without medical supervision include:<\/span><\/p>\n<figure id=\"attachment_40197\" aria-describedby=\"caption-attachment-40197\" style=\"width: 857px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\" wp-image-40197\" src=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1348724431-612x612-1-300x200.jpg\" alt=\"A box of generic Gabapentin pills. \" width=\"857\" height=\"571\" srcset=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1348724431-612x612-1-300x200.jpg 300w, https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1348724431-612x612-1.jpg 612w\" sizes=\"(max-width: 857px) 100vw, 857px\" \/><figcaption id=\"caption-attachment-40197\" class=\"wp-caption-text\">Source: iStock<\/figcaption><\/figure>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Divalproex sodium (Depakote\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clobazam (Onfi\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.veriheal.com\/blog\/is-medical-cannabis-a-match-to-anticonvulsant-medications-like-gabapentin\/\"><span style=\"font-weight: 400;\">Gabapentin<\/span><\/a><span style=\"font-weight: 400;\"> (Neurontin\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carbamazepine (Tegretol\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lamotrigine (Lamictal\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Topiramate (Topamax\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phenytoin (Dilantin\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ethosuximide (Zarontin\u00ae)<\/span><\/li>\n<\/ul>\n<h2><b>9.<\/b><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span><b>Asthma Meds<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Smoking or vaping cannabis, if you have asthma, is obviously ill-advised because it can worsen your respiratory health. Even if you don\u2019t vape or smoke, cannabinoids can still pose a risk if you\u2019re on asthma medication. Fortunately, emergency, life-saving asthma medicines like albuterol are not affected by cannabinoids.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Your body breaks down some asthma meds using <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31433338\/#:~:text=Conclusions%3A%20Medications,affect%20CBD%20disposition.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CYP1A2<\/span><\/a><span style=\"font-weight: 400;\">, which is one of the enzymes that metabolize THC and CBD. As such, cannabinoids may interfere with how your body processes other asthma drugs, potentially causing dangerous drug level fluctuations. Possible adverse effects include increased heart rate, anxiety, dizziness, and trouble breathing, which is a big problem if you have asthma.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Asthma drugs not to mix with cannabis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theophylline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Montelukast (Singulair\u00ae)<\/span><\/li>\n<\/ul>\n<h2><b>10.<\/b><span style=\"font-weight: 400;\">\u00a0 <\/span><b>Antipsychotics<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Living with mental illness is hard, but with the right antipsychotic medication, a functional life becomes possible. However, cannabis can lower the effectiveness of antipsychotics and cause symptoms to resurge or even worsen.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Why? Many antipsychotics work by controlling dopamine activity. THC, which is a psychoactive compound, can interfere with this by increasing dopamine activity and counteracting the medication\u2019s effects. This may worsen symptoms like paranoia, hallucinations, or anxiety.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of antipsychotics you shouldn\u2019t use with cannabis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clozapine (Clozaril\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Olanzapine (Zyprexa\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risperidone (Risperdal\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quetiapine (Seroquel\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aripiprazole (Abilify\u00ae)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">While THC can make things worse for people with psychosis, CBD is emerging as a <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0074774224000655#:~:text=Cannabidiol%20(CBD)%20is%20a,treatment%20of%20schizophrenia.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">promising antipsychotic alternative<\/span><\/a><span style=\"font-weight: 400;\"> or adjunct that offers multiple direct therapeutic effects while <\/span><a href=\"https:\/\/www.cell.com\/trends\/pharmacological-sciences\/fulltext\/S0165-6147(24)00271-2#:~:text=in%20therapeutic%20response.-,Psychoses,further%20clarify%20its%20therapeutic%20potential%20in%20this%20context%20(Table%203).,-ASD\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">enhancing antipsychotic signalling<\/span><\/a><span style=\"font-weight: 400;\">. Attentive psychiatric care is needed for carefully combining CBD and conventional approaches.<\/span><\/p>\n<h2><b>11.<\/b> <b>Stimulants<\/b><\/h2>\n<figure id=\"attachment_40198\" aria-describedby=\"caption-attachment-40198\" style=\"width: 842px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\" wp-image-40198\" src=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1346785597-612x612-1-300x216.jpg\" alt=\"Methylphenidate, MP, MPH molecule. It is central nervous system stimulant. Used in treatment of Attention-Deficit Hyperactivity Disorder, ADHD. \" width=\"842\" height=\"606\" srcset=\"https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1346785597-612x612-1-300x216.jpg 300w, https:\/\/www.veriheal.com\/blog\/wp-content\/uploads\/2025\/10\/istockphoto-1346785597-612x612-1.jpg 612w\" sizes=\"(max-width: 842px) 100vw, 842px\" \/><figcaption id=\"caption-attachment-40198\" class=\"wp-caption-text\">Source: iStock<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Stimulants boost dopamine levels to help you focus and stay alert. Since cannabis, especially CBD, has an opposing effect, it can reduce the stimulant\u2019s effect, making it harder to concentrate. This can trick you into using <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11032069\/#S7:~:text=One%20of%20the%20shared,in%20adverse%20physical%20outcomes.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">higher doses<\/span><\/a><span style=\"font-weight: 400;\"> and increase the <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11032069\/#S7:~:text=Furthermore%2C%20those%20with,15%2C18\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk of dependence<\/span><\/a><span style=\"font-weight: 400;\"> or side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Also, since stimulants and THC can raise blood pressure and heart rate, combining the two can put you at risk of<\/span><a href=\"https:\/\/www.veriheal.com\/blog\/new-study-finds-yet-another-link-between-cannabis-and-heart-disease\/\"> <span style=\"font-weight: 400;\">cardiovascular issues<\/span><\/a><span style=\"font-weight: 400;\">. For these reasons, don\u2019t mix these prescription stimulants with weed:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amphetamine (Adderall\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methylphenidate (Ritalin\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lisdexamfetamine (Vyvanse\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methylphenidate (Concerta\u00ae)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dextroamphetamine (Dexedrine\u00ae)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">On a case-by-case basis, your doctor may decide if it\u2019s OK for you to mix THC, CBD, or both with your ADHD medicine, depending on your age, insight, and circumstances. Some adult patients can successfully use cannabis and ADHD meds under supervision for improving ADHD symptoms and alleviating the <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11032069\/#S7:~:text=For%20the%20subset,improved%20sleep%20problems.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">possible side effects<\/span><\/a><span style=\"font-weight: 400;\"> of ADHD meds, like sleeping issues and appetite loss.<\/span><\/p>\n<h2><b>12.<\/b> <b>Heart Medication<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Several types of heart medications are available, and they help improve heart health through various means. For instance, some lower blood pressure, while others regulate heart rhythm to reduce the risk of heart attacks or strokes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">THC, especially at high doses, can have the opposite effect and increase heart rate and blood pressure in the short term until it is metabolized. This <\/span><a href=\"https:\/\/www.veriheal.com\/blog\/experts-warn-that-cannabis-can-interfere-with-certain-heart-medications\/\"><span style=\"font-weight: 400;\">counteracts your heart meds<\/span><\/a><span style=\"font-weight: 400;\">, putting you at risk of complications like arrhythmias, chest pain, or even dangerous cardiac events.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are on any of these prescription heart drugs, talk to your doctor before using cannabis:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beta-blockers like metoprolol, atenolol, and propranolol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calcium channel blockers like amlodipine, diltiazem, and verapamil<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antiarrhythmics like amiodarone, flecainide, and sotalol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardiac glycosides like digoxin, digitoxin, and ouabain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ACE inhibitors or ARBs like lisinopril, enalapril, losartan, and valsartan<\/span><\/li>\n<\/ul>\n<h2><b>Use Cannabis Safely<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Keep in mind that our list of medications you should never mix with cannabis is NOT exhaustive! For your safety, don\u2019t combine recreational or medical cannabis use with any other recreational substances like alcohol, or medication your body might process with <\/span><b>CYP450 enzymes<\/b><span style=\"font-weight: 400;\"> (like CYP3A4, CYP2C9, CYP2D6, CYP1A2) and <\/span><b>UGT enzymes<\/b><span style=\"font-weight: 400;\"> (like UGT1A9 or UGT2B7). This is the vast majority of medications, so it\u2019s important to be cautious first and talk to your provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Your liver uses these enzymes to break down both cannabinoids and many prescription drugs. Combining both can lead to unpredictable drug levels, stronger side effects, increased toxicity, or reduced treatment effectiveness. However, it\u2019s not a hard stop since your doctor should know how to evaluate these relative risks, order necessary labs, and make any dosage adjustments.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So, if you\u2019re on any medication, including those not on our list, please consult your doctor before using cannabis in any form. They\u2019ll let you know if it\u2019s safe to use with your medication and how to use the combination with fewer risks.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cannabis by itself poses very little to no risk to most people. But that changes when you incorrectly use it, and one of the most dangerous mistakes you can make is mixing cannabis with certain medications by yourself. Why? Some medications become toxic when used alongside cannabis, while others may lose their effectiveness, leaving your&#8230;<\/p>\n","protected":false},"author":106,"featured_media":40199,"parent":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15362],"tags":[17860,17360,13660,61,136,18582,17451,18581,206,217,17274],"class_list":["post-40195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-guides","tag-cannabis-and-medication","tag-cannabis-health-risks","tag-cannabis-safety","tag-cbd","tag-medical-cannabis","tag-opoids","tag-prescription-drugs","tag-safe-cannabis-use","tag-thc","tag-veriheal","tag-weed-interactions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v26.1.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Medications You Shouldn\u2019t Mix With Cannabis<\/title>\n<meta name=\"description\" content=\"Mixing cannabis with some medications can be risky. Learn which 12 drugs you should never combine with cannabis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.veriheal.com\/blog\/medications-to-avoid-mixing-with-cannabis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"12 Medications You Should Never Mix With Cannabis\" \/>\n<meta property=\"og:description\" content=\"Mixing cannabis with some medications can be risky. 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