Minnesota’s medical cannabis program covers 19 listed qualifying conditions, plus any condition for which your health care practitioner has recommended cannabis. Knowing where your diagnosis fits is the first step toward enrollment. This guide covers every listed condition under Minn. Stat. §342.01, subdivision 63. For each one, it explains what the condition means clinically and what a certifying practitioner will need to see from you.
Minnesota’s medical cannabis program launched in 2015 and is now administered by the Office of Cannabis Management’s Division of Medical Cannabis. Unlike a traditional prescription, a medical cannabis certification is entered directly into the state registry by your certifying practitioner. You do not receive a paper prescription to fill at a dispensary.
Minnesota legalized adult-use cannabis in August 2023 for adults 21 and older, but the medical program remains a separate track. Registered patients are exempt from Minnesota’s 15% cannabis tax on medical purchases, according to the Minnesota Department of Revenue. Patients under 21 can also access cannabis only through the medical program. If you are weighing the medical program against recreational access, the benefits of a medical marijuana card are worth reading. That decision is separate from the eligibility question this article answers, though.
The condition list below reflects current law. Laws change, so verify current rules with the Division of Medical Cannabis before you begin enrolling.
Every condition below appears in Minn. Stat. §342.01, subdivision 63. For each one, your certifying practitioner will review your medical history and confirm your diagnosis before entering your certification into the registry.
Alzheimer’s disease is a progressive neurological disorder that destroys memory and other important mental functions. It qualifies because patients often experience agitation, anxiety, and sleep disturbances that standard medications do not consistently address. Practitioners will look for a neurologist’s or geriatric specialist’s documentation of the diagnosis.
Autism spectrum disorder (ASD) is a developmental condition affecting communication, behavior, and social interaction across a wide range of presentations. Minnesota’s statute requires that the diagnosis meet the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). Some patients, particularly those with severe behavioral symptoms that have not responded to other interventions, may benefit from cannabis as part of a broader treatment plan. A formal diagnosis from a psychologist, psychiatrist, or developmental pediatrician is typically required.
Cancer refers to any malignant disease in which abnormal cells divide uncontrollably and can invade other tissues. Minnesota’s statute covers cancer when the condition or its treatment produces severe or chronic pain, nausea or severe vomiting, or cachexia or severe wasting. A certifying practitioner will typically look for pathology reports, oncology records, or treatment documentation confirming the diagnosis and those symptoms.
Chronic motor or vocal tic disorder involves repetitive, involuntary movements or vocal sounds that persist over time without meeting the full criteria for Tourette syndrome. It qualifies because some patients experience tics that do not respond adequately to standard treatments. Practitioners will look for a neurologist’s diagnosis and documentation of treatment history.
Chronic pain refers generally to pain that persists over an extended period and affects daily functioning. Minnesota lists it separately from intractable pain, which broadened access for patients whose pain is long-standing but who have not necessarily exhausted every treatment option. The distinction between the two categories is covered in the section below the list.
Glaucoma is a group of eye conditions that damage the optic nerve, often because of elevated pressure in the eye. It is a leading cause of blindness. Research has examined cannabis and eye pressure for decades, which is why glaucoma was one of the original qualifying conditions in many state programs, including Minnesota’s. Practitioners will generally want to see a diagnosis from an ophthalmologist and documentation of current treatment.
Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) qualify because patients often experience chronic pain, nausea, and significant weight loss. Conventional treatments do not always fully address these symptoms. Cannabis has been studied for its potential to support appetite and reduce nausea in this population, according to research summarized by the National Center for Complementary and Integrative Health. Your certifying practitioner will typically review your infectious disease records or a letter from your treating physician.
Intractable pain qualifies as defined in Minn. Stat. §152.125, which describes pain whose cause cannot be removed or otherwise treated and for which no relief or cure has been found after reasonable efforts. Certification typically requires a documented history of treatment attempts, such as medications, physical therapy, or procedures that have not produced adequate relief.
Obstructive sleep apnea (OSA) is a condition in which the throat muscles intermittently relax and block the airway during sleep, causing disrupted breathing and poor sleep quality. It qualifies in part because some patients do not tolerate standard treatments such as continuous positive airway pressure (CPAP) therapy. A sleep study result or a diagnosis from a pulmonologist or sleep medicine specialist will typically be required.
Post-traumatic stress disorder (PTSD) is a mental health condition triggered by experiencing or witnessing a traumatic event, causing symptoms such as flashbacks, severe anxiety, and intrusive thoughts. It qualifies because conventional treatments do not work for every patient. Practitioners will typically need a formal PTSD diagnosis from a mental health professional and documentation of current or prior treatment.
Generalized anxiety disorder is not one of Minnesota’s 19 listed conditions, and in 2021 the state declined to add it to the list. However, Minnesota law now also covers any condition for which your practitioner recommends cannabis, so talk with your practitioner about your specific situation rather than assuming you do not qualify.
Tourette syndrome is a neurological disorder characterized by repetitive, involuntary movements and vocalizations called tics. It qualifies because some patients experience tics that do not respond adequately to standard pharmacological treatments. Practitioners will look for a neurologist’s diagnosis and documentation of treatment history.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to loss of muscle control. Patients often experience severe muscle spasms, pain, and difficulty swallowing, and cannabis may offer palliative relief. Certification typically requires a neurologist’s diagnosis or documentation from a specialist managing ALS care.
Seizures are episodes of abnormal electrical activity in the brain that can cause a wide range of symptoms, from brief lapses in awareness to full convulsions. Epilepsy is the most common condition that causes chronic seizures. Cannabidiol (CBD) has received significant clinical attention for reducing seizures, including the FDA’s 2018 approval of a CBD-based drug for Dravet syndrome and Lennox-Gastaut syndrome. Practitioners will generally look for neurology records, seizure frequency documentation, and a history of treatment attempts.
Severe and persistent muscle spasms can result from a range of conditions, but multiple sclerosis (MS) is one of the most common causes. MS is an autoimmune disease that damages the protective covering of nerve fibers, disrupting communication between the brain and body. Practitioners will want documentation of the underlying condition and a record of spasm frequency or severity.
Inflammatory bowel disease (IBD) covers chronic inflammation of the gastrointestinal tract, most commonly Crohn’s disease and ulcerative colitis. These conditions cause pain, severe diarrhea, fatigue, and malnutrition, and symptoms often persist despite standard treatment. Some patients report that cannabis helps with pain and appetite, though it is not considered a treatment for the underlying inflammation. Gastroenterology records confirming the diagnosis and treatment history are typically what practitioners need.
Irritable bowel syndrome (IBS) is a common disorder of the digestive tract that causes cramping, abdominal pain, bloating, and changes in bowel habits, without the inflammation seen in IBD. It qualifies because symptoms can be persistent and difficult to manage with standard approaches. Practitioners will typically look for a gastroenterologist’s or primary care diagnosis and treatment history.
Obsessive-compulsive disorder (OCD) is a mental health condition marked by unwanted, intrusive thoughts and repetitive behaviors that a person feels driven to perform. It qualifies because some patients do not respond fully to conventional therapy and medication. A formal diagnosis from a mental health professional and a record of treatment history are typically required.
Sickle cell disease is an inherited blood disorder in which red blood cells become misshapen and break down, causing episodes of severe pain known as sickle cell crises. It qualifies because pain management in sickle cell disease is a persistent clinical challenge. Practitioners will typically want hematology records or a documented diagnosis from a physician managing your care.
Minnesota covers a terminal illness with a probable life expectancy of under one year when the illness or its treatment produces severe or chronic pain, nausea or severe vomiting, or cachexia or severe wasting. This category recognizes the palliative role cannabis can play in end-of-life care. A practitioner will need documentation from your treating physician confirming the prognosis.
Beyond the 19 listed conditions, Minnesota’s definition of a qualifying medical condition also includes any condition for which your health care practitioner has recommended, approved, or authorized the use of cannabis. This means the list is not closed. If your diagnosis is not named above, your practitioner can still evaluate whether cannabis is appropriate for you.
Intractable pain and chronic pain appear as separate entries in Minn. Stat. §342.01, subdivision 63, but patients, and sometimes practitioners, treat them as interchangeable. They are not, and the difference affects what documentation you will need.
| Intractable Pain | Chronic Pain | |
| Definition | Pain whose cause cannot be removed or otherwise treated, with no relief or cure found after reasonable efforts (Minn. Stat. §152.125) | Pain that has lasted over time and affects your daily functioning |
| What it focuses on | The failure of conventional treatment | How long the pain has lasted and how it affects your life |
| Typical documentation | A history of treatment attempts, such as medications, injections, physical therapy, or other interventions | A long-standing pain diagnosis, even if you have tried fewer treatments |
| May fit you if | Your records show multiple failed treatments | Your records show long-term pain but limited treatment history |
Either way, a practitioner must confirm your diagnosis. Veriheal’s practitioners can help you understand which category your records are most likely to support.
Patients with conditions such as fibromyalgia, chronic Lyme disease, or other diagnoses not named among the 19 listed conditions are not automatically excluded. Minnesota law counts any condition for which your practitioner has recommended or authorized cannabis as a qualifying medical condition.
That means the key step is a conversation with your practitioner, not a petition. Your practitioner will review your history, consider whether cannabis is appropriate for your condition, and, if so, certify you. Many conditions also overlap with a listed category. Fibromyalgia, for example, frequently involves chronic pain.
Before assuming you do not qualify, speak with a practitioner about your situation. Getting a clear answer about your existing records is the fastest path forward.
Getting a medical cannabis card in Minnesota is not especially difficult if you have a qualifying condition and the documentation to support it. The process has two steps: getting certified by a practitioner, then completing your enrollment application with the Division of Medical Cannabis. Many practitioners offer certification visits by telehealth.
Beyond a qualifying condition, these rules determine who can enroll:
To see how other states handle visiting patients, check out which states allow out-of-state patients to buy medical cannabis. For a broader comparison, medical card state-by-state laws shows how Minnesota’s rules stack up against other programs.
Most problems with a Minnesota application come down to missing documentation rather than outright ineligibility. Understanding the grounds for denial helps you avoid the most common pitfalls.
Under Minn. Stat. §342.52, subdivision 4, the office may deny enrollment only if you:
You must also be a Minnesota resident to meet the definition of a patient. If the office denies your enrollment, it must give you written notice of all its reasons. A denial is a final decision that can be reviewed in court under Minnesota’s administrative procedure law.
Working with a practitioner who knows the certification requirements reduces the risk of documentation problems. It is also worth understanding how long it takes to get a medical card so you can plan your timeline.
At your certification appointment, your practitioner reviews your medical history and confirms your qualifying condition. They must be a Minnesota-licensed doctor of medicine, physician assistant, or advanced practice registered nurse with primary responsibility for treating your condition.
Here’s what happens from there:
There is no state enrollment fee, and enrollment is valid for three years. Many patients complete the certification visit by video. If you want to learn how telemedicine for medical cannabis works in different states, that guide covers it.
If you think you may qualify, check your condition with a Veriheal practitioner through a telehealth appointment. Every Veriheal evaluation comes with a “get approved or your money back” policy.
Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.
Note: Veriheal does not support illegally consuming therapeutic substances such as cannabis but acknowledges that it transpires because of the current illicit status, which we strive to change by advocating for research, legal access, and responsible consumption. Always consult a physician before attempting alternative therapies.
Generalized anxiety disorder is not one of Minnesota’s 19 listed conditions. However, the law also covers any condition for which your practitioner recommends cannabis, so talk with a practitioner about your specific situation before concluding you do not qualify.
Most denials come down to missing paperwork, not ineligibility. Under Minn. Stat. §342.52, the office can deny enrollment if you don’t submit a practitioner certification, don’t sign the required disclosure, leave out required information, or provide false information. Enrollment in a federally approved clinical trial for your condition that uses medical cannabis is also grounds for denial. Only Minnesota residents can qualify.
Adult-use cannabis has been legal in Minnesota for adults 21 and older since August 2023, and the medical program is administered separately by the Office of Cannabis Management’s Division of Medical Cannabis. The Legislature amended Chapter 342 again in 2026, so check the Division of Medical Cannabis for the latest rules before you rely on any specific detail here.
No, for most patients with a qualifying condition. You get certified by a practitioner, complete a free enrollment application, and the office decides within 30 days. Having your medical records ready is the best way to avoid delays.
It can. Federal law, 18 U.S.C. §922(g)(3), still bars unlawful users of controlled substances from possessing firearms. State-licensed medical marijuana moved to Schedule III in April 2026. In June 2026, the Supreme Court ruled in United States v. Hemani that prosecuting someone for marijuana use alone violates the Second Amendment. But the statute and ATF Form 4473 remain unchanged. If this is a concern for you, review the breakdown of medical cannabis cards and gun rights before enrolling.
Generally, no. Medical cannabis is not an FDA-approved prescription drug, so health insurance does not typically cover it, and that has not changed with its move to Schedule III. The guide on whether medical cannabis is covered by insurance covers what patients pay out of pocket.
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Anxiety is not explicitly listed as a qualifying condition for medical marijuana in Florida, but patients may qualify through the state’s comparable-condition provision. This guide explains physician eligibility assessments, required medical documentation, in-person evaluations, cannabis product considerations, application fees, and potential implications for firearm ownership.
Renewing a Virginia medical marijuana certification requires an annual evaluation with an authorized practitioner, while renewing the state-issued identification card is optional. This guide explains the online renewal process, associated fees, when to renew, what happens if certification expires, and the requirements for caregivers of minor patients.
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