News, Research

Ediblocked: Why Can’t Some People Get High From Edibles?

June 21, 2021 08:00 am ET
Ediblocked: Why Can’t Some People Get High From Edibles?

Have you ever shared some edibles between friends, only to discover that one of you is feeling nothing at all? Well, Al McDonald has. The Boston Globe presented Al McDonald’s story as an example of a situation where a group of friends shared “a strong batch of pot-infused cookies” but he “got absolutely nothing from them”. McDonald even stated that he sat there like “aww man… everybody’s Hoverboard works except for mine”. McDonald represents the group of people who have a hard time getting high from edibles, which seems to have stumped scientists. 

People Who Are ‘Ediblocked’ Are Unaffected by Edibles

McDonald forms part of an “unknown portion of the population that appears to be functionally ‘immune’ to edibles, or at least has exceptionally high tolerances”. The Boston Globe describes this group of people as being “ediblocked” but also explains that when they smoke cannabis, they experience it as normal. Persons who are classified as ediblocked are said to be able to consume quantities of cannabis that would send the majority of people on an intense trip, while they experience nothing.

McDonald was reported to have engaged in a rather “reckless experiment” where he consumed hash tea and only began to feel something at around 700 milligrams of THC. To put that in perspective, 700 milligrams is 140 times the “standard serving in Massachusetts of 5 milligrams”. Additionally, it is recommended that consumers of cannabis begin with 1.2-5mg of THC as well as capping it at 10mg under normal circumstances in order to minimize adverse effects associated with high THC potency. Cannabis should contain around 10% or less THC to be considered effective, low-potency, and a lower risk of adverse effects such as increased anxiety. 

The Boston Globe goes on to explain that researchers and medical professionals are aware of and acknowledge the phenomenon of being ‘ediblocked’ but are not able to “definitively explain it”. They also explain that this can have “serious implications for dosing in medical marijuana treatment” as well as arousing questions on the validity of the blood tests which indicate cannabis-related impairment. 

Researchers Hypothesize That the Answer Might be in the Liver

The director of the Marijuana Investigations for Neuroscientific Discovery programs at the McLean Hospital, Dr. Staci Gruber, stated that “we’re only just now starting to understand the cannabinoid system” and that “it’s already clear that it’s not just about what and how much you’re using; it’s about how you’re wired”. 

Currently, there is limited research on persons with “ultra-high tolerances to marijuana edibles” however, Dr. Gruber and other researchers have a “compelling hypothesis”. The hypothesis is that those who are ‘ediblocked’ have an unusual variation of a “key liver enzyme” which could “essentially be too efficient at processing ingested THC, turning the compound into its ‘active’ high-inducing metabolite and then its inactive waste product before the active form can enter the bloodstream or brain”. 

However, there is another similar possibility which includes being “unusually inefficient at performing this process, with little THC getting metabolized in the first place”. Dr. Gurber explains that “it’s almost as if they’re skipping the intermediate step”. He also explains that the people with the uncommon CYP2C9 gene are breaking down the cannabinoid so fast that “it doesn’t have an opportunity to create the psychoactive effect”. 

What Is The CYP1C9 Gene and How Does it Impact THC Levels in the Body?

MedlinePlus explains that the CYP2C9 gene “provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport”. They go on to explain that the CYP2C9 enzyme plays an important role in the metabolism and breaking down of drugs including warfarin and ibuprofen. The Boston Globe also explains that it also “encodes the enzyme that shepherds THC through its three-step metabolic transformation”. While Dr. Gruber adds that the individuals with the gene are “breaking it down so fast it doesn’t have an opportunity to create the psychoactive effect”. 

A 2020 study found that the levels of THC metabolites found in the consumer’s blood varied drastically “depending on which variant of the enzyme they had”. The research from this study “casts doubt on biological marijuana tests widely used by researchers, doctors, police, and employers”. These tests do not account for the “apparently vast and hard-wired variations in metabolic rate between individuals”. Dr. Gruber explains that “it underscores the need to understand people’s genetic profile, and that there are a lot of variables people haven’t considered” such as whether one has the uncommon CYP2C9 enzyme. 

The Problem With Being Ediblocked

Being ‘ediblocked’ poses a problem for those who wish to medicate with cannabis by means of oral ingestion as opposed to inhalation methods. When one is unable to feel the effects of edibles, or cannabis which is swallowed, they may experience ‘social FOMO’ or the inability to benefit from the pain-relieving and other medicinal properties which cannabis contains. Edibles make for a good alternative means of cannabis consumption which smoking is not an option. The Boston Globe states that these ‘ediblocked’ individuals could benefit from the relief of cannabis through edibles if they took a “high enough dose, or if a supplement could be developed that slows their enzyme action”. 

While there is not enough research to support the hypothesis at the moment, the study and the researchers make valid points. Hopefully, research can be conducted to support the suggestions and findings so that we can find solutions for those individuals as well as for improving the means by which we measure cannabis impairment. 

Post Your Comments

Shana B says:

June 22, 2021 at 3:01 pm

Literally thought I was the only one that could eat a dozen cookies and all I get is a extra pound added on.

Reply
Patricia A Jennings says:

June 22, 2021 at 3:15 pm

That’s funny!

Reply
Barflecopter says:

June 22, 2021 at 3:06 pm

I am one of those people. Sublingual however, does work for me. I advise anyone having issues with being ediblocked to try using tinctures or distillates sublingually. It works!

Reply
Patricia A Jennings says:

June 22, 2021 at 3:14 pm

I tried them too and wondered why I felt nothing. But if I took two puffs of something of high potency I would be laid to the side ugh!!!

Reply
Mark Bondi says:

June 22, 2021 at 3:16 pm

That’s a very insightful article and good to know. I am one of those people. I have eaten well over 500mg RSO and/or distillate only to be highly disappointed. 🥲

Reply
CJ says:

June 22, 2021 at 7:41 pm

I also found that I don’t get high from edibles. Curious, though, whether others who experience this DO get the dry mouth and munchies without the high like I do?

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Chane Leigh says:

June 24, 2021 at 3:41 pm

Good question and definitely something worth investigating!

Reply
Peter says:

June 25, 2021 at 7:51 pm

I have eaten edibles and I’ve gotten high. You you still get cotton mouth and snacky.

Reply
CieCie says:

June 22, 2021 at 5:02 pm

Edibles and tinctures…neither works for me

Reply
Josh Saxon says:

June 22, 2021 at 5:21 pm

Wow No Shit…I think that story might be right..I Never feel shit when I eat edibles..I have a couple times with friends everyone got fucked up but me..I have to smoke it to get high..

Reply
Elizabeth Colon says:

June 22, 2021 at 5:25 pm

It helps me eat and not to hurt my self

Reply
Rob says:

June 22, 2021 at 6:30 pm

I’ve tried 1000mg chocolate bar, nothing. Tried the 10:1 tincture under the tongue, nothing. 2 of them the next time, nothing but a really good poop. God dam you CYP2C9!!! I really want to experience an edible high

Reply
Chane Leigh says:

June 24, 2021 at 3:46 pm

I hope they are able to produce a product to slow the action of the CYP2C9, so that you (and all the other ediblocked persons) can experience and benefit from the edibles.

Reply
Thomas Heaney says:

June 25, 2021 at 4:24 pm

Great article. I guess I am mostly ediblocked. When I tried edibles a few times it did nothing for me so I ate more and more, until I got a headache that lasted a couple of days. Only once or twice when I was in the right setting and just sitting and listening did I ever have the euphoric feeling and then it was more of a body high rather than Mindy high. IT was like hashish that I used to get from Morocco.

Reply
Peter says:

June 25, 2021 at 7:48 pm

Just a thank you for all the info you share with us.

Reply
Angela Greene says:

June 29, 2021 at 10:03 pm

This is really a relief because for the longest time I couldn’t figure out why I was the only one that it had no effect on …everyone thought I was just lying about it… I live in Florida and I visited a friend in California and she gave me 400 mg edible.. I accidentally thought she meant to eat the whole thing and I felt nothing.. she had a small piece and went and laid down…

Reply
Mark Stephenson says:

July 3, 2021 at 2:13 pm

Yea I can get 1000+ mil from a despsence and nothing like a hang over the next day is all i get

Reply
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