It seems to be taking a lifetime to establish some kind of measurable consistency or regularity in cannabis effects. Throwing us another curveball, it seems that women may need less tetrahydrocannabinol (THC) than men do, in order to feel the same effects. According to newly published research by Dr. J. Matheson in the Psychopharmacology Journal, women were able to feel the same acute effects of cannabis consumed as the men did…but at a lower dosage.
Acute effects refer to the effects produced immediately after cannabis consumption and during the psychoactive effects. Acute effects are impacted by factors such as tobacco, alcohol, experience, age and now, apparently gender too.
Examples of acute effects include a shift in general mood, a change in physical experience as well as changes in how we perceive through the senses. This means that you can go from being shy to talkative, from uptight to carefree, from stiff to relaxed as well as boosting tactile impressions.
Dr. Justin Matheson, a Ph.D. candidate at the University of Toronto, did a study that displayed that men are more likely to consume more cannabis than women but that women are also more likely to experience the more severe effects which may stem from cannabis consumption. Dr. Matheson and his colleges aimed to offer secondary analysis to “examine sex differences in THC” between the sexes.
Dr. Matheson and his team did the study as a secondary analysis of a study that found “robust sex differences” in animal studies. This animal study suggests that women may need less cannabis for THC because it turns out they may be more sensitive to the effects. The research suggested that females metabolized cannabis differently to men, but remember… the research is also lacking human evidence.
The secondary analysis led by Dr. Matheson included regular cannabis consumers aged 19-25 years old as participants. There were 91 participants in total and they made use of a randomized cannabis/placebo in a 2:1 ration. This means that 17 women and 43 males received cannabis while 9 females and 21 males received a placebo. The study took multiple tests of measurements including blood samples to get the number of cannabis concentrations for cannabinoids such as the THC. They also checked vital signs, tested cognition abilities, and measured subjective effects.
The results of this secondary analysis found that women had a “lower peak concentration of THC” and that the blood THC concentrations remained lower in women but other than that, there was no sign of any other differences. These results came after they made adjustments for differences in estimated doses of THC inhaled. Dr. Matheson stated that
“What I want to stress here though is that, in our study, participants were able to smoke the amount of cannabis they wanted to. When participants smoke to their desired high, we call this ‘titrating to effect.’ Titrating to effect is possible when smoking cannabis because THC delivery to the brain is very rapid with this route of administration, so users can feel the high as they are still smoking — with other cannabis products like edibles or beverages that have a delayed onset of action, it is not possible to titrate to effect. In these cases, women are likely at higher risk of experiencing acute harms”.
They concluded that women experienced the same acute effects as men, even though they had lower dosages. They also stated that their research was just more proof that we need to do more research on the sex differences in the pharmacology of cannabis. Dr. Matheson explained that their next step is to answer why there are differences between sexes when it comes to cannabis consumption. For now, all we know is that women usually tend to smoke less than men but experience similar effects as them.
I do not know about you but needing less weed as a woman, means more for me in the end… and that makes me happy!
“Do you prefer an indica or a sativa?” is typically the first question asked at a dispensary. Indica vs. sativa refers to the two main categories of cannabis strains. Both indicas and sativas differ in appearance and effects. Indicas are generally known for a sedating effect, while sativa strains are known for a cerebral high….
According to research, “Migraine is highly prevalent, affecting 12% of the population, attacking up to 17% of women and 6% of men yearly. Among children, it tends to happen more in girls than boys.” A migraine can be very disabling and last from hours to two or three days. Migraines are considered to be the…
PTSD can have far-reaching effects on health, functionality as well as on quality of living, which is why having access to effective treatment is so important. If you are living with PTSD or are living with someone who has PTSD, you would have first-hand experience with how challenging it can be getting through life on…
Up until recently, lack of cannabis education meant that people were blissfully unaware of the fact that the plant is not limited to just one strain and, therefore, does not produce just one type of effect. Fortunately, agricultural experimentation has led to the market exploding in terms of strains that can satisfy everyone, from beginners…
Using cannabis to help combat anxiety is a tricky business. Studies have given us significant evidence that cannabis can be used to help cope with anxiety and because anxiety is so common, that’s an extremely welcome piece of information. In fact, 72% of daily cannabis users reported consumption to relax or relieve tension and 58%…
Side hustle: Many of us have one (or more) to help make some extra for things we need and want in life—things…
Ohio introduced a legalization bill, cannabis and psilocybin could be the future of cancer care, and a ketamine company is looking to…
A bill was passed to legalize the possession and sharing of certain psychedelics for Californians aged 21 and above. The bill underwent…