Have you ever considered using cannabis to treat your depression? If so, you’re not alone. In fact, a growing number of people are turning to this herbal remedy to help improve their mood. But if you’re taking the antidepressant Wellbutrin (bupropion), is it safe to use cannabis at the same time? Here are some facts you should know before deciding what is right for you.
Wellbutrin, a brand of bupropion, is a prescription medication that is used to treat major depressive disorder and seasonal affective disorder. Wellbutrin is also sometimes used as a smoking cessation aid, as it can help to reduce nicotine cravings and withdrawal symptoms. A regular or extended-release tablet is available depending on the individual’s response to the medication.
Some common side effects of Wellbutrin include:
Over time, these side effects usually diminish as the body adjusts to the medication. Generally, Wellbutrin causes few side effects and works well for treating depression.
Bupropion works by increasing the levels of norepinephrine and dopamine, types of neurotransmitters, in the brain. In other words, it helps keep those feel-good neurotransmitters circulating for longer, allowing us to make better use of them. As a result, patients who take Wellbutrin may experience a boost in mood and energy levels.
According to a study published by Advances in Experimental Medicine and Biology in 2021, scientists found cannabis to be an effective remedy for depression.
When combined with Wellbutrin, cannabis improved the medication’s effectiveness and reduced unpleasant side effects. Also, there is evidence that cannabinoids found in cannabis, such as cannabidiol (CBD), boost neurotransmitter activity and reduce inflammation. Thus, combining CBD-rich cannabis with Wellbutrin may help improve its overall efficacy.
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In light of the increase in acceptance and popularity of cannabis, it’s essential to consider any potential interactions with other medications when using the plant. Although many people report positive outcomes when cannabis is combined with Wellbutrin, research suggests the combination may worsen depression for some people, while anxiety or insomnia may increase for others.
Additionally, researchers have explored whether Wellbutrin could help ease cannabis withdrawal symptoms for people attempting to stop using the plant. While marijuana is not commonly thought of as causing physical withdrawal effects, many people develop a psychological dependence on it and can experience withdrawal symptoms when they try to quit.
Some people report that Wellbutrin has helped ease their withdrawal symptoms. However, for some frequent marijuana connoisseurs, other evidence suggests that the antidepressant may actually worsen moods during marijuana withdrawal.
Here are a few tips that may help you if you opt to use cannabis and Wellbutrin together:
With a little trial and error, you should be able to find the right combination that works for you.
If you’re thinking about combining Wellbutrin and cannabis, the best thing to do is talk to your doctor or pharmacist first. They will be able to educate you on possible risks and drug interactions that could occur. While many people can safely combine these two substances, it’s important to understand that every person is different and that what may work for one person might not work for another, so be ready to make adjustments to your routine as necessary for the best possible outcome.
Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.
I take Wellbutrin and recently have given up nicotine completely while still smoking cannabis. In my personal opinion it helps a great deal. I also only smoke cannabis in way lower amounts than before as well. I’ve used the plant to help sleep when up at night. Also I used it to fight some of the nausea when I first started taking it. I’m an avid cannabis user and have been for a long time. When I say Wellbutrin has helped me cut my smoking nicotine to a zero and cannabis to a very low consumption amount as well.
I’ve taken wellbutrin and additional MMJ for ~2 years and I think it’s really combated my seasonal affective disorder. I’d recommend sticking to sativas that are high in limonène if you want to increase your mood.
Could you clarify how cannabis improves bupropion’s effectiveness? I followed the link and did not see anything indicating this to be the case, but medical research is far out of my knowledge base. The conclusion of the paper says bupropion reduces the subjective effects of marijuana and enhances the subjective effects of marijuana withdrawal, which I interpret as: the high is weaker, the withdrawals worse. And I don’t see anything about improvement of medication effectiveness.
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