Many people use cannabis frequently to treat diseases and conditions, especially those involving pain. Due to such frequent use, it is perfectly normal and natural to develop a tolerance to cannabis. This means that frequent consumers of cannabis eventually need to consume more to feel the same effects as before the development of their tolerance.
In relation to cannabis, tolerance is the brain’s adaptation to the continued presence of psychoactive cannabinoids like THC, but not non-intoxicating cannabinoids like CBD. Consumers of THC-containing cannabis, therefore, become resistant to the effects of cannabis resulting in the consumption of larger amounts. Tolerance increases are not limited to cannabis and include a wide number of substances and stimuli such as caffeine, alcohol, painkillers, and many routine prescription medications. Note the important distinction that developing a tolerance is not the same as having a substance use disorder or addiction.
Tolerance build-ups are caused by what is called downregulation and desensitization where the receptors for THC reduce in the brain. It has been proven that frequent users have 20% fewer CB1 receptors than those who do not consume cannabis frequently. CB1 is the receptor that tetrahydrocannabinol (THC) binds with. However, the variety of receptors that cannabis reacts with can be regenerated through the effective use of tolerance breaks.
It only takes two days to four weeks of abstinence to regenerate those receptors. A study has shown that it does not matter how much cannabis you consume; the receptors start to grow back after just two days. However, this study was conducted using males only, and cannabis is widely believed to affect women differently.
THC is known to activate the CB1 receptor, which is what causes euphoria and eventually tolerance in humans. Other cannabinoids, like CBD, do not directly activate the CB1 receptor, which is why they do not cause a high. According to the WHO, CBD does not cause a tolerance effect in humans the same way THC does. Thus, there is no dependence potential with CBD, and in fact, CBD may even reduce the psychoactive rewards and effects of THC. Other minor cannabinoids are still under investigation in this regard.
Taking tolerance breaks and other measures to reduce the tolerance build-up will ensure that you will continue to achieve the same benefits and effects you’re after without increasing your consumption.
The following are some suggestions for maintaining a comfortable tolerance to cannabis.
For more information, check out How to Lower Your Cannabis Tolerance
If you use cannabis frequently—particularly for recreational purposes—a tolerance break is a great way to reset. Here are some tips for a successful tolerance break:
For medical cannabis consumers who rely on the plant’s therapeutic properties to manage conditions, tolerance breaks aren’t always ideal. Here are some ways to get the most out of your medicine:
Always keep the good news in mind: the changes from cannabis to your receptors are reversible through tolerance breaks and effective management of your consumption. Tolerance breaks are important if you find yourself needing to take a larger amount in order to reach the desired effects. They can seem daunting but are very beneficial and rewarding. Happy toking!
Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.
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