Research, Treatment

Cannabinoid Acids Explained: The Precursors to Cannabinoids

February 23, 2022 08:00 am ET
Cannabinoid Acids Explained: The Precursors to Cannabinoids

Cannabis is probably one of the most complex plants in the world, with over 400 chemical entities. Of these, more than 60 are cannabinoids like THC that interact with our bodies to produce effects and benefits. But what many cannabis consumers don’t know is that cannabis doesn’t naturally contain the activated cannabinoids we all know and love. Rather, cannabinoids begin their lives as molecules known as cannabinoid acids.

What Are Cannabinoid Acids?

According to the Journal of Natural Products, cannabinoid acids are acid precursors that are dominant in the plant. Essentially, cannabinoid acids are the original form of cannabinoids and have a slightly different chemical structure—that is, they have a carboxylic acid ring. This ring is removed through the process of decarboxylation, which involves exposing the cannabis to heat or light. The end result is an activated cannabinoid that affects the body much differently when consumed.

A study published in 2019 explains that all cannabinoid acids are characterized by the presence of an alkyl side chain, and most of them are formed with five carbon atoms. However, some are formed with three carbon atoms, making them “varinoids.” These ones, such as tetrahydrocannabivarinic acid (THCVA), are easy to spot on paper due to the presence of “varin” in their names. Finally, though rare, some contain only one carbon atom and are called orcinoids.

A team of researchers from the University of Campania in Italy explained that the benefits of cannabinoid acids are being largely overlooked despite a growing interest in them. According to the team’s 2020 study, cannabinoid acids do not induce any psychotropic effects. Considering how much safer this makes them for widespread consumption—particularly for individuals who cannot ingest the intoxicating THC—many in the industry are uncertain they’re not receiving the same attention as cannabinoids.

Types of Cannabinoid Acids and Their Potential Benefits

As pointed out above, research into the effects of cannabinoid acids is still in a very early stage. However, some preliminary studies have discovered a variety of potential benefits offered by some of these molecules, justifying further experimentation.

As you can see by the abbreviations of the cannabinoid acid names, they lose an “A” once the carboxylic acid ring is removed by means of decarboxylation (e.g., THCA becomes THC). This is indicative of the structural changes being made to the atoms when exposed to heat.

THCA: Delta-9-tetrahydrocannabinolic Acid

THCA, also known as 2-carboxy-THC, has the ability to reduce inflammation, inhibit tumor growth in prostate cancer, treat nausea, act as a neuroprotectant (against seizures), and manage chronic pain.

When THCA is subjected to the decarboxylation process, it becomes THC.

CBDA: Cannabidiolic Acid

CBDA shares many of its benefits with its better-known compound CBD, such as being able to reduce inflammation, alleviate nausea and vomiting, and act as an anticonvulsant. It also has anti-carcinogenic properties for battling pain and cancer.

When CBDA is subjected to the decarboxylation process, it becomes CBD.

CBCA: Cannabichromenic Acid

CBCA has been shown to have antidepressant, anti-cancer, anti-bacterial, anti-fungal, and anti-inflammatory properties while also being able to promote healthy cell growth and relieve pain. It may also help relieve pain, nausea and vomiting, and improve appetite and muscle spasticity.

When CBCA is subjected to the decarboxylation process, it becomes CBC.

CBGA: Cannabigerolic Acid

CBGA, which is often referred to as the mother of all cannabinoids, was found to be even more effective at reducing seizures than CBD, making it a powerful anticonvulsant along with its benefits of being anti-inflammatory, anti-proliferative, antibacterial, and analgesic (pain-relieving). Its properties may be particularly beneficial in diabetes and cancer.

When CBGA is subjected to the decarboxylation process, it becomes CBG. CBGA is the parent molecule of many of our favorite major and minor cannabinoids.

CBGVA: Cannabigerovarinic Acid

CBGVA is suggested to be an anti-inflammatory agent that is particularly beneficial against glaucoma. It also has the potential benefits of being antibacterial and analgesic and might help to alleviate nausea and vomiting.

When CBGVA is subjected to the decarboxylation process, it becomes CBGV.

CBDVA: Cannabidivarinic Acid

Much like many other CBD-based cannabinoid acids, CBDVA has been suggested to be effective in reducing the frequency and severity of seizures, alleviating nausea, being anti-inflammatory and analgesic, and managing mood disorders.

When CBDVA is subjected to the decarboxylation process, it becomes CBDV.

CBCVA: Cannabichromevarinic Acid

CBCVA is said to be highly effective as a painkiller in addition to having antifungal, anti-bacterial, anti-inflammatory, antipsychotic, and antidepressant properties. It is also suggested to be effective against acne and diarrhea as well as being effective as an immunomodulator and neuroprotectant.

When CBCVA is subjected to the decarboxylation process, it becomes CBCA.

THCVA: Tetrahydrocannabivarinic Acid

THCVA is suggested to be effective as an appetite suppressant while defending against chemotherapy-induced nausea and vomiting, regulating blood sugar levels, reducing insulin resistance, and having anticonvulsant, antioxidant, and neuroprotective properties.

When THCVA is subjected to the decarboxylation process, it becomes THCV.


Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before making any decision on the treatment of a medical condition.

Post Your Comments

Content Medically Reviewed By:<br> Dr. Abraham Benavides, MD
Content Medically Reviewed By:
Dr. Abraham Benavides, MD


Learn More About The Experts

{"post_type":"post","post_status":"publish","posts_per_page":3,"post__not_in":[20541,1185,10697,25767,22915,25856,25944,25778,25756,25749,25516,25383]}

Latest News

February 3, 2023
NYC’s Social Equity Success Story, Mississippi Opens Medical Market, & Hong Kong Bans CBD

New York City’s newest recreational dispensary is a big win, Mississippi opened its medical cannabis market, and Hong Kong banned CBD. Let’s…

January 27, 2023
Veriheal 5 Spotlight: TerraLeaf Dispensaries

We sat down with the team at TerraLeaf, a medical cannabis dispensary servicing West Virginia, to ask them the Veriheal 5—five questions…

January 19, 2023
Nevada Rules That the Schedule I Classification of Cannabis Is Unconstitutional

The war on drugs facilitated by the federal government has been an utter failure. Despite cannabis remaining a Schedule I classification according…