Top Conditions Treated by Cannabis Doctors in 2025

In 2025, patients will increasingly seek out cannabis doctors to manage persistent symptoms and complex conditions. As medical marijuana research and patient support grow, more states are broadening access through expanded medical marijuana programs.

Here’s a look at the conditions cannabis doctors treat most often and how qualifying conditions for medical marijuana continue to evolve nationwide.

How Are Conditions Approved for Medical Marijuana?

Each state sets its own rules for approving qualifying conditions for medical marijuana. Most start with legislation or ballot measures that outline an initial list. In some states, the medical board can even add conditions through public petitions and rule changes.

After legalization, certified cannabis doctors review each patient’s diagnosis and confirm it matches an approved condition. In other states, patients must first try traditional treatments before getting certified, unless cannabis is already standard care for that condition.

Some states give doctors broad authority to recommend cannabis for any debilitating condition. Others use tiered lists and update them regularly through their respective health agencies. 

However, most medical marijuana state programs blend legal guidelines with physician judgment. This approach keeps qualifying conditions rooted in evidence while allowing room for updates as cannabis research evolves.

Top Medical Conditions Managed by Cannabis Doctors in 2025

Below are the top medical marijuana qualifying conditions that cannabis doctors help patients with most often in 2025. The list begins with emerging uses and leads up to the most common reasons patients seek medical marijuana today.

Crohn’s Disease: Cannabis doctors commonly recommend tetrahydrocannabinol (THC) and cannabidiol (CBD) products to ease intestinal inflammation and cramping. Crohn’s continues to rise as a qualifying condition for medical marijuana when standard medications fail.

Seizure Disorders: High‑CBD extracts like Epidiolex® can reduce seizure frequency in hard‑to‑treat epilepsy, although nonpharmaceutical formulation results may vary. Seizure disorders remain one of the most common medical conditions that cannabis doctors help manage. Liver enzymes will need to be monitored, and anticonvulsant medications may need to be adjusted by your doctor.

Cancer‑Related Symptoms: Medical marijuana helps fight chemo-related nausea, increase appetite, and relieve nerve pain. Cancer remains among the top conditions doctors can help manage with cannabis, thanks to consistent patient-reported benefits for both cancer and treatment-related symptoms.

Immune Deficiency (e.g., HIV, AIDS, etc.): Patients with immune system disorders use low‑dose THC to ease nerve pain and improve appetite and CBD for mood and deeper sleep, offering a gentler alternative to many pharmaceutical options.

Persistent Nausea: Medical marijuana, especially via inhalation consumption methods, delivers fast relief for nausea linked to migraines, GI flare-ups, or recovery from surgery. Nausea now ranks as one of the fastest-growing qualifying conditions for medical marijuana.

Arthritis: Patients turn to cannabis in both systemic and topical forms to help reduce joint swelling, pain, and morning stiffness, making it a common go-to natural alternative to NSAIDs (i.e., ibuprofen) or acetaminophen (i.e., Tylenol®).

Muscle Spasms: Patients with multiple sclerosis, spinal injuries, or neurological conditions use medicinal marijuana to relax muscles and improve sleep, keeping spasms high on the list of cannabis doctors’ most treated conditions.

Chronic Pain: Cannabis doctors rely on full-spectrum products to help patients manage conditions like fibromyalgia, back pain, and arthritis. Cannabis can lower pain scores and can cut opioid use, making chronic pain the most common medical condition cannabis doctors treat.

Trouble Sleeping (Insomnia): Sleep-related issues top the list in 2025. Patients use cannabis to fall asleep faster and stay asleep longer. According to the American Academy of Sleep Medicine, over 50% of cannabis patients use it for sleeping issues, making insomnia among the top 3  reasons people seek medical cannabis today.

New or Emerging Conditions in 2025

In 2025, more people are turning to cannabis to manage a wider variety of health issues—not just the ones it’s most commonly known for. 

While conditions like chronic pain still top the list, new surveys and reports show growing interest in using cannabis for other conditions, too. Patients are reporting relief from symptoms tied to everything from anxiety to autoimmune disorders, and research is beginning to catch up.

Patients and cannabis doctors are also increasingly turning to lesser-known cannabinoids beyond THC and CBD to treat a broader range of conditions. Minor or rare cannabinoids, such as cannabigerol (CBG), can help combat anxiety, inflammation, and bacteria; cannabinol (CBN) can promote better sleep; and tetrahydrocannabivarin THCV can help curb appetite and help support blood sugar control.

Some of the top new and emerging conditions people manage with medical marijuana in 2025 include:

Neurological Disorders: Patients and researchers are showing more interest in cannabis for conditions like Parkinson’s disease and Huntington’s disease. While further studies are needed, many patients report relief from the symptoms of these conditions, such as muscle spasms, tremors, mood, and sleep disturbances.

Mental Health Conditions: Cannabis is already well-known for helping with PTSD and anxiety, but more patients are now using it to manage depression and other mood disorders like seasonal affective disorder (SAD). Medical marijuana consumers often report improved emotional balance, lower stress, and better sleep.

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Gastrointestinal Issues: People with ulcerative colitis, Crohn’s, irritable bowel syndrome, and other digestive conditions are turning to cannabis to help manage bowel movements, inflammation, nausea, and pain.

Chronic Illnesses and Symptoms: Beyond just chronic pain, using cannabis to help with conditions like migraines and even symptoms related to diabetes. Many patients report reduced discomfort and better daily function.

PTSD: Both veterans and civilians with PTSD continue to report that cannabis helps ease flashbacks, anxiety, and sleep problems. 

Opioid Alternatives: Some patients turn to cannabis as a safer alternative to opioids, especially for long-term symptom management. Research shows many people find cannabis just as effective as their prescription meds, but with fewer side effects. This points to medical marijuana’s potential to reduce dependency risks and improve overall quality of life.

Other Conditions: Patients turn to cannabis for managing new and different conditions each year, such as Tourette’s syndrome.

Pediatric and Geriatric Conditions

Patients of all ages, from children to older adults, use medical cannabis to manage a wide range of health conditions.

Pediatric Conditions

The American Academy of Pediatrics supports the use of FDA-approved medical cannabis for children facing life-limiting or severely debilitating conditions, especially when other treatments haven’t worked. 

In these cases, medical marijuana may help manage pediatric conditions symptoms related to:

• Epilepsy and Seizure Disorders: Children with severe epilepsy, including Dravet and Lennox-Gastaut syndromes, often see fewer seizures and a better quality of life with CBD treatments like Epidiolex®, used alongside other medications for drug-resistant cases. 
• Autism Spectrum Disorder (ASD): Research shows that CBD-rich cannabis extracts may help children and teens with autism. In one 2025 study, kids with severe, treatment-resistant autism experienced fewer disruptive behaviors, less anxiety, reduced medications, and better social engagement after using purified CBD. Other cannabinoids like CBDV are promising and are currently being investigated. 
• Chemotherapy Side Effects: Medical cannabis is showing promise in easing chemotherapy-induced nausea and vomiting in pediatric cancer patients, offering much-needed relief during treatment. This effect is well-established in adults, but is currently undergoing observational safety evaluation in children due to possible detrimental developmental effects. 
• Chronic Pain and Palliative Care: While research is still limited in kids, early studies suggest that medical cannabis may help with chronic pain and improve comfort for children in palliative care settings when other treatments fall short.
  

Geriatric Conditions

Cannabis use is on the rise among older adults nationwide, as more people turn to medical cannabis as a safe, natural, and effective way to manage geriatric conditions.

• Chronic Pain: In 2025, multiple studies confirm that more seniors are using cannabis while reporting less reliance on prescription meds and an overall boost in quality of life. Some older patients with chronic pain report responding better to cannabis than to many traditional painkillers. 
• Sleep Issues: Indica and hybrid strains are helping older adults fall asleep faster and stay asleep longer. Patients, especially older adults, report better sleep while relying less on prescription sleep aids. 
• Alzheimer’s and Dementia: Cannabis-derived medications may ease agitation, anxiety, and discomfort in patients with advanced Alzheimer’s or dementia. One long-term clinical trial showed that a synthetic THC medication helped reduce agitation over time. 
• Parkinson’s Disease: While not a cure, cannabis can help manage symptoms like tremors, muscle stiffness, and pain caused by Parkinson’s Disease. Parkinson’s patients using cannabis commonly report that their quality of life has improved significantly.

READ: What Does Research Say About Psychedelic Therapy for Autism?

State-by-State Differences in Qualifying Conditions

As of mid-2025, 40 states, D.C., and three U.S. territories have legalized medical cannabis. Eight additional states allow only low-THC, high-CBD programs. Medical cannabis programs across the United States can differ not only in access but also in which medical conditions qualify for medical marijuana.

Examples of State Differences

Some of the differences in qualifying conditions for medical marijuana programs by state include:

• Ohio: Lists 21 qualifying conditions, including PTSD, chronic pain, and Crohn’s disease. However, it allows public petitions for new additions, making it one of the more flexible programs. 
• New Jersey: The state’s “Jake’s Law” expanded medical marijuana access to include anxiety, migraines, opioid use disorder, and more. It also allows regulators to add new conditions over time easily. 
• Louisiana: The state doesn’t rely on a set list of qualifying conditions. Any condition a doctor deems debilitating qualifies, giving physicians expansive authority. 
• Texas: Allows only low-THC cannabis for a narrow list, like epilepsy, cancer, and PTSD, making it one of the most restrictive medical cannabis programs. 
• New Mexico: Covers over 25 conditions, including substance use disorder and Alzheimer’s. They also approve cannabis for chronic symptoms like severe nausea, even without a listed diagnosis. 

• Kentucky: Previously, only allowing CBD, a complete medical program started in January 2025. Legislators tied program funding to peer-reviewed evidence showing efficacy for qualifying conditions like cancer, ALS, chronic pain, epilepsy, PTSD, and nausea.

Frequently Asked Questions 

What conditions qualify for medical marijuana?

Each state sets its list of qualifying conditions, but many commonly include chronic pain, PTSD, epilepsy, cancer, and multiple sclerosis. Many also approve conditions like anxiety, migraines, autism, and IBD. Some states, such as Louisiana, grant doctors the freedom to certify any condition they deem debilitating.

Can you get medical marijuana for anxiety?

Yes, anxiety ranks among the top reasons patients visit cannabis doctors. Many states list it as a qualifying condition, particularly for individuals seeking improved sleep and stress relief.

Is chronic pain a qualifying condition for MMJ?

Yes, cannabis doctors treat chronic pain more than any other condition. Patients with fibromyalgia, arthritis, and back pain commonly use cannabis to manage symptoms and reduce their reliance on opioids and other painkillers.

Does PTSD qualify for medical marijuana?

Yes, most U.S. states recognize PTSD as a qualifying condition. Veterans and civilians commonly report fewer flashbacks, better sleep, and reduced anxiety with medical marijuana. 

What are the new MMJ qualifying conditions in 2025?

While each state has its own qualifying conditions, states are beginning to approve additional conditions like Parkinson’s disease, autism, sickle cell disease, cachexia, Tourette syndrome, and opioid use disorder. Many also add symptom-driven conditions such as insomnia, chronic nausea, and muscle spasms.

Can autism be treated with cannabis?

Yes, in some states. CBD-rich cannabis can help those with severe, treatment-resistant autism by easing anxiety and reducing disruptive behaviors. 

Can you use MMJ for depression or other mental health issues?

Yes. While not all states list depression as a qualifying condition, many cannabis doctors treat it, especially when linked to other conditions like anxiety, PTSD, or insomnia.