Your medical cannabis journey simplified: find partnered dispensaries, explore pricing options, earn rewards, and get answers to FAQs, all in one spot.
Note: Veriheal does not support illegally consuming therapeutic substances like psilocybin magic mushrooms but acknowledges that it transpires because of the current illicit status of both, which we strive to change by advocating for research, legal access, and responsible consumption. Always consult a physician before attempting alternative therapies.
The National Institute of Mental Health estimates that there are around 19.4 million adults in America who’ve faced at least one depressive episode in their lifetime – most of which are able to improve through the help of antidepressant treatments (9). However, there are still many others who are faced with treatment-resistant depression that remains persistent despite efforts for improvement.
Finding a Solution for Treatment-Resistant Depression is Vital
Treatment-resistant depression is when an individual with depression does not adequately respond to standard treatments. In other words, treatment for depression is not sufficiently alleviating their symptoms after 1 or more trials of antidepressants or counseling. Normally, an individual would be taking antidepressants for 6-8 weeks and/or undergoing psychological counseling – which would then begin to alleviate the depression. So what happens when your depression is not responding to months of treatment?
Leading health organizations such as The Mayo Clinic and the American Academy of Family Physicians often outline strategies, several of which are medication-based and combined with psychotherapy (6) (5). Those strategies include giving current medication more time, increasing the dose, and switching antidepressants…so many pharmaceuticals which are all associated with side effects such as nausea, weight gain, blurred vision, insomnia, loss of sexual drive, etc. It may normally take several months to find the right medication and dosage for you, which takes patience and commitment. Fortunately, recent research on psilocybin shows promise for how using the botanical substance may help alleviate treatment-resistant depression.
The acclaimed author of Harry Potter, J.K Rowling, stated that “It’s so difficult to describe depression to someone who’s never been there because it’s not sadness. I know sadness. Sadness is to cry and to feel. But it’s that cold absence of feeling—that really hollowed-out feeling (7).” Depression can be lonely and even dangerous when left unchecked- which is what makes finding alleviation for treatment-resistant depression so vital.
For more on depression, be sure to check out this article.
How Can Psilocybin Assist?
In order to understand how psilocybin can assist with treatment-resistant depression (TRD), let’s have a look at this 2021 published study which found that psilocybin may work as effectively as escitalopram, a common antidepressant– now I know what you’re thinking… “How can such a substance assist when they may only work as effectively as the current medication proved ineffective for this type of depression (2)?” Well, let’s find out.
The study compared the effectiveness of commonly prescribed antidepressants with therapeutic doses of psilocybin (2). While the study did find psilocybin effective for depression, it also found a significant difference in antidepressant effects between psilocybin and escitalopram (a common antidepressant). The secondary outcomes also generally favored psilocybin, though not statistically corrected for.
See If You Qualify For Medical Marijuana -Select Your State!
Despite the fact that psilocybin did not prove to be more effective than antidepressants, another study found that two doses of psilocybin were more effective than common treatments in terms of assisting with TRD (3). In both of these studies, patients also received psychological support. The TRD study conducted theirs on the basis that “clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy (3).”
Researchers Carhart-Harris (also first author of the 2021 study), Bolstridge, Day, and the team sought to report on the safety and efficacy of the outcomes of psilocybin on TRD for up to six months in an open-label trial. The team of researchers found that the psilocybin was well tolerated by the participants and that reductions in depressive symptoms were observed within1-5 weeks post-treatment. At the same time, 5 weeks post-treatment, “nine and four patients met the criteria for response and remission at week 5 (1).”
Additionally, at the 5-week mark, none of the participants sought out further antidepressant treatment after having been treated with psilocybin. When assessing the participants again, the team found a continuing positive response to the psilocybin at 3 and 6 months. After 3 months, a few patients sought out additional treatments including antidepressants (6 patients), therapy (5 patients), or more psilocybin (5 patients) (1).
The team concluded by stating that despite the limited conclusions which can be made from an open-label trial, they found that “tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort (1).”
Psilocybin Interacts With Serotonin Receptors
The relationship between serotonin and depression is explained by the fact that serotonin is the brain’s “happy” chemical that influences mood. Higher levels of serotonin are linked to elevated mood and feeling happy, whereas lower levels of serotonin are linked to sadness and depression (8).
The psilocybin in magic mushrooms, or shrooms, has the ability to deliver mind-altering, neuroplastic effects which is why people with depression can benefit from the substance. psilocybin has a high affinity for several serotonin receptors which are located in numerous areas of the brain, including the cerebral cortex and thalamus (1).
Since psilocybin has a “high affinity” for the receptors of this “happy” chemical, it stands to reason that psilocybin can boost the chemical, thereby gearing consumers towards the state associated with higher levels of serotonin (1). This is what researchers are confirming and why it makes for a viable and effective means of alleviating depression. Psilocybin and other serotonergic psychedelics may also help rewire brain connections, a property called neuroplasticity, which could explain its lasting effects months after consumption (4). Unfortunately, limited research is being conducted since the substance is still widely illegal.
Psilocybin is quickly gaining support for its continued promise as a powerful therapeutic substance with the potential to alleviate an array of conditions – much like cannabis. At the moment, it is anyone’s guess as to whether the psilocybin will be removed from its federally-imposed Schedule 1 listing. Fortunately, research such as this provides hope where some may feel there is none- such as is the case in treatment-resistant depression.
1. Carhart-Harris, R.L., Bolstridge, M., Day, C.M.J. et al. Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology 235, 399–408 (2018). https://link.springer.com/article/10.1007/s00213-017-4771-x
2. Carhart-Harris, R., Giribaldi, B., Watts, R., Baker-Jones, M., Murphy-Beiner, A., Murphy, R., Martell, J., Blemings, A., Erritzoe, D., & Nutt, D. J. (2021). Trial of psilocybin versus escitalopram for depression. New England Journal of Medicine, 384(15), 1402–1411. https://www.nejm.org/doi/full/10.1056/NEJMoa2032994
5. Maurer, D. M., Raymond, T. J., & Davis, B. N. (2018, October 15). Depression: Screening and diagnosis. American Family Physician. Retrieved January 2, 2022, from https://www.aafp.org/afp/2018/1015/p508.html
8. Priory Group. (n.d.). What is the link between serotonin and depression? Priory. Retrieved January 2, 2022, from https://www.priorygroup.com/blog/what-is-the-link-between-serotonin-and-depression
Chane Leigh, aka The Bud Fairy, is a South African cannabis advocate and enthusiast with a firey personality and a thirst for travel. She loves to educate people and to question the norms.
Migraines are far more debilitating than typical headaches, often disrupting daily life. More and more people are turning to cannabis to manage their chronic pain, with migraines being the top reason among headache patients. Cannabis is such a powerful tool for migraine and pain relief that many patients even use medical marijuana in place of…
We all know honey comes from bees, and bees need flowers to make honey, so does this mean bees can make infused honey from the flowers of the cannabis plant? The details are more complicated than you’d think. Cannabis flowers don’t produce nectar, so bees can’t make honey from them. Since cannabis plants pollinate via…
Over the last decade, there has been considerable discussion about the future of cannabis. Typically, those conversations center around legality, market size, and social and medical impacts, all of which are interesting topics in their own right. But there has been far less discussion about the digital future of cannabis. With more and more of…
Talking to your family about cannabis can be difficult. You’re often battling with generations of stigma and the impacts of changing social norms in real time. Conversing with a grandparent who grew up believing that cannabis is bad and those who smoke weed are lazy, among other sentiments, can be challenging. With that in mind,…
With so many Western contexts for cannabis (legal dispensaries, lounges, education pathways, etc), we sometimes forget the big picture. The history of cannabis use spans centuries, with unique applications across China, India, and many other regions. Throughout centuries of use, many cultures have developed traditions that are still in practice today. One scarcely documented example…
The statements made regarding cannabis products on this website have not been evaluated by the Food and Drug Administration (FDA). Cannabis is not an FDA-approved substance and is still illegal under federal law. The information provided on this website is intended for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. It is not intended as medical advice and should not be considered as a substitute for advice from a healthcare professional. We strongly recommend that you consult with a physician or other qualified healthcare provider before using any cannabis products. The use of any information provided on this website is solely at your own risk.
1. Carhart-Harris, R.L., Bolstridge, M., Day, C.M.J. et al. Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology 235, 399–408 (2018). https://link.springer.com/article/10.1007/s00213-017-4771-x
2. Carhart-Harris, R., Giribaldi, B., Watts, R., Baker-Jones, M., Murphy-Beiner, A., Murphy, R., Martell, J., Blemings, A., Erritzoe, D., & Nutt, D. J. (2021). Trial of psilocybin versus escitalopram for depression. New England Journal of Medicine, 384(15), 1402–1411. https://www.nejm.org/doi/full/10.1056/NEJMoa2032994
5. Maurer, D. M., Raymond, T. J., & Davis, B. N. (2018, October 15). Depression: Screening and diagnosis. American Family Physician. Retrieved January 2, 2022, from https://www.aafp.org/afp/2018/1015/p508.html
8. Priory Group. (n.d.). What is the link between serotonin and depression? Priory. Retrieved January 2, 2022, from https://www.priorygroup.com/blog/what-is-the-link-between-serotonin-and-depression