Cannabis and CBD for Movement Disorders
Movement disorders are characterized by impaired, or involuntary movements, or both. Targeting and speed of the intended movements can be disrupted, unwelcome movements, irregular poses or repetitive, inopportunely or unintendedly normal movements may be obstructed. They may be caused by diseases, genetic conditions, medications, or other factors.
Movement Disorders are neurological conditions caused by motion and posture abnormalities. Such disorders are linked to brain cell changes that help us move. These changes can cause unwanted or excessive motions, known as hyperkinesia. Other changes to the brain cell function, called Hypokinesia, may cause a lack of automatic and intended movements not related to weakness or spasticity. The following conditions include movement disorders:
- Parkinson’s Disease
- Parkinsonian syndromes (progressive supranuclear palsy, multiple system atrophy, cortical basal degeneration)
- Huntington’s disease
- Restless legs syndrome
- Tourette’s syndrome
- Wilson disease
Partial or complete paralysis may be part of the physical symptoms of neurological problems. The weakness of the muscle, the loss of sensation is partial or full. While genetic or medical defects, brain damage, spinoid damage or peripheral nerves, diabetes, stroke, vascular illness, and contaminants, are the common cause of this kind of disease.
How Cannabis Can Help Relieve the Symptoms of Movement Disorders
CBD is a major chemical compound found in cannabis. It does not produce the effects of feeling high, which are caused by THC. Two of more than 100 cannabinoids in cannabis, both CBD and THC, interact with the body’s endocannabinoid system, a neurotransmitter network that controls diverse physiological and cognition processes and stress response.
Cannabis has been used in many cultures for medicinal and spiritual purposes and recreational purposes for many years due to its psychoactive properties. In the last three decades, a wide range of tissues including peripheral nerves and the Central Nervous System have been identified for cannabinoid receptors and cannabinoids developed in an endogenous manner. The Endocannabinoid system (ECS), including thinking, mood, regulation of the brain, feeding, and pain, has been involved in a wide range of physiological functions. Although the health benefit of cannabinoids is widespread, more pre-clinical and clinical research is required to enhance the pharmacological, physiologic and therapeutic impact of this class of medicinal products for motion disorders.
Medical Cannabis Treatment for Movement Disorders
Parkinson’s disease (PD) and l-DOPA (LID) are both caused by Movement Disorders which has a direct effect on the quality of life of a person. Sadly, pharmacological therapies that improve these conditions are not yet available without causing serious side effects. Delay is no longer recommended as LID development is not cumulative l-DOPA exposure, but depends on the duration of the disease. Manipulation of the endocannabinoid system can be a promising treatment to manage symptoms of PD and LID.
Therefore, the key non-psychotomimetic component of the cannabis sativa plant has been given significant attention over the last ten years by phytocannabinoids and by synthetic cannabinoids such as cannabidiol (CBD). Researchers present clinical and pre-clinical evidence to support the therapeutic effects of CBD and other cannabinoids in PD and LID. The pharmacology of CBD and its neuroprotective effects and those of other cannabinoids were discussed as well as the modulation of several pro- or anti-inflammatory factors as possible mechanisms responsible for the therapeutic/neuroprotective potential of Cannabis-derived/cannabinoid synthetic compounds in motor disorders.